Definition of the Carbohydrate Response Element of the Rat SI4 Gene

Definition of the Carbohydrate Response Element of the Rat SI4 Gene
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大鼠 SI4 基因碳水化合物反应元件的定义

DOI:
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发表时间:
1994
期刊:
影响因子:
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通讯作者:
Howard C. TowleS
Howard C. TowleS
中科院分区:
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文献类型:
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作者:
H. Shih;Howard C. TowleS

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家务活。在瞬时转染实验中,-1457和-1450之间的上游位点突变不影响对高糖的反应,而下游21个碱基在-1448和-1428之间的位点不足以介导葡萄糖诱导。电泳法迁移率改变分析表明,肝脏因子结合到这个部位
ChoRE. In transient transfection experiments, mu- tation of the upstream site between -1457 and -1450 did not affect the response to elevated glucose, whereas the downstream 21-bp site between -1448 and -1428 was suf- ficient to mediate the glucose induction. Electro- phoretic mobility shift assays indicated that the hepatic factor binding to this site