The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database
The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database
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DOI：
10.1183/13993003.00154-2016
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发表时间：
2017-01-01
影响因子：
24.3
通讯作者：
Vogelmeier, Claus Franz
中科院分区：
文献类型：
--
作者：
Greulich, Timm;Nell, Christoph;Vogelmeier, Claus Franz
α(1)-抗胰蛋白酶缺乏症 (AATD) 是一种由基因决定的疾病，与不同的临床表现相关。我们的目的是使用大型医疗保健数据库来评估诊断 AATD 及其合并症的患病率。在这项回顾性纵向观察研究中，我们分析了 400 万投保人的数据。使用国际疾病分类修订版 10 (ICD-10) 代码，我们评估了 AATD 患者（E88.0 重复编码）相对于患有慢性阻塞性肺疾病 (COPD)、肺气肿或哮喘的非 AATD 患者的患病率、合并症和医疗保健利用率。在我们的研究人群中，我们确定了 673 名 AATD 患者（590 岁，30 岁），对应于 在所有年龄组中，患病率为每 10 万人 23.73 人，在这些年龄组中，患病率为每 10 万人 29.36 人。 30年。根据样本量中检测到的 AATD 病例数（2836 585 例中的 673 例），我们推断在研究期间德国有 19 162 例 AATD 病例。相对于非 AATD 哮喘或肺气肿患者，AATD 患者动脉高血压、慢性肾病和糖尿病的患病率较高。与非 AATD 慢性阻塞性肺病患者相比，AATD 患者的就诊次数明显增多，住院时间也更频繁、住院时间更长。我们的数据强化了 AATD 与多种其他疾病相关的假设。与患有非 AATD 相关阻塞性肺病的患者相比，AATD 患者的医疗保健利用率似乎更高。
alpha(1)-Antitrypsin deficiency (AATD) is a genetically determined disorder that is associated with different clinical manifestations. We aimed to assess the prevalence of diagnosed AATD and its comorbidities using a large healthcare database.In this retrospective longitudinal observational study, we analysed data from 4 million insurants. Using International Classification of Diseases revision 10 (ICD-10) codes, we assessed the prevalence, comorbidities and healthcare utilisation of AATD patients (E88.0 repeatedly coded) relative to non-AATD patients with chronic obstructive pulmonary disease (COPD), emphysema or asthma.In our study population, we identified 673 AATD patients (590 aged. 30 years), corresponding to a prevalence of 23.73 per 100 000 in all age groups and 29.36 per 100000 in those. 30 years. Based on the number of AATD cases detected in the sample size (673 out of 2836 585), we extrapolated that there were 19 162 AATD cases in Germany during the years studied. AATD patients had a higher prevalence of arterial hypertension, chronic kidney disease and diabetes relative to non-AATD asthma or emphysema patients. When compared to non-AATD COPD patients, AATD patients had significantly more consultations and more frequent and longer hospitalisations.Our data strengthen the assumption that AATD is associated with a variety of other diseases. Healthcare utilisation appears to be higher among AATD patients as compared to patients with non-AATD-related obstructive lung diseases.