A stable lanthanide-functionalized nanoscale metal-organic framework as a fluorescent probe for pH
A stable lanthanide-functionalized nanoscale metal-organic framework as a fluorescent probe for pH
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稳定的镧系元素功能化纳米级金属有机框架作为 pH 荧光探针
DOI：
10.1016/j.snb.2017.07.172
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Qian Guodong
中科院分区：
文献类型：
--
作者：
Zhang Xin;Jiang Ke;He Huajun;Yue Dan;Zhao Dian;Cui Yuanjing;Yang Yu;Qian Guodong
通过在孔中封装Eu 3+阳离子，制备了基于合成后修饰的纳米UiO-67-bpydc的荧光pH传感器。掺入Eu 3+的样品（Eu 3 +@UiO-67-bpydc）由于母体骨架提供的敏化和保护而显示出优异的发光。随后，Eu 3 +@UiO-67-bpydc被开发为pH传感器。Eu 3 +@UiO-67-bpydc对pH范围为1.06 - 10.99的酸性和碱性溶液都显示出良好的耐化学性，这使得它有可能用于宽范围pH传感器。此外，循环实验已经证明了传感器的可利用性。MTT分析表明，Eu 3 +@UiO-67-bpydc具有良好的生物相容性。此外，还在PC 12细胞中进行了Eu 3 +@UiO-67-bpydc的荧光成像，以测试其在体内的可行性。由于其优异的稳定性和pH依赖性的荧光强度，荧光探针应该是一个有前途的候选人，在体外和体内的荧光pH传感应用。
A fluorescent pH sensor based on post-synthetically modified nanoscale UiO-67-bpydc by encapsulating Eu3+cations in the pores was fabricated. The Eu3+incorporated sample (Eu3+@UiO-67-bpydc) shows excellent luminescence due to the sensitization and protection provided by the parented framework. Subsequently, Eu3+@UiO-67-bpydc was developed as a pH sensor. Eu3+@UiO-67-bpydc shows good chemical resistance to both acidity and alkalinity solutions with pH ranging from 1.06 to 10.99, which makes it potentially useful for wide-range pH sensor. In addition, cycling experiments have demonstrated the utilizability of the sensor. The MTT analysis shows that Eu3+@UiO-67-bpydc possesses favourable biocompatibility. Furthermore, fluorescence imaging of Eu3+@UiO-67-bpydc in PC12 cells was also performed to test its feasibility in vivo. Given its exceptional stability and pH-dependent fluorescent intensity, the fluorescent probe should be a promising candidate for application in fluorescent pH sensing in vitro and in vivo.
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