Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV
Potential role of the melanocortin signaling system interference in the excess weight gain associated to some antiretroviral drugs in people living with HIV
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DOI：
10.1038/s41366-020-0551-5
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发表时间：
2020-02-20
影响因子：
4.9
通讯作者：
Domingo, Joan Carles
中科院分区：
文献类型：
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作者：
Domingo, Pere;Villarroya, Francesc;Domingo, Joan Carles
暴露于某些抗逆转录病毒药物，特别是基于整合酶链转移抑制剂（INsTI）的联合抗逆转录病毒疗法（cART）与艾滋病毒感染者（PLWH）体重增加有关，超过了“恢复健康”的现象。尽管体重增加和肥胖是多因素的，但PLWH中常见的流行病学联系是基于INsTI的cART。在这里，我们假设，干扰黑皮质素系统（MCS）功能的INsTI在PLWH的体重增加和肥胖中起着至关重要的作用，类似于一般人群中黑皮质素受体（MCR）突变和精神病患者抗精神病药物治疗引起的干扰。
Exposure to some antiretroviral drugs, especially integrase strand transfer inhibitors (INsTI)-based combination antiretroviral therapy (cART) has been associated with weight gain in people living with HIV (PLWH) exceeding what would be a "return to health" phenomenon. Notwithstanding the fact that weight gain and obesity are multifactorial, the common epidemiological link in PLWH is INsTI-based cART. Here, we postulate that interference with the melanocortin system (MCS) functioning by INsTI plays an essential role in excess weight gain and obesity in PLWH, similar to disturbances caused by melanocortin receptor (MCR) mutations in the general population and by antipsychotic therapy in psychiatric patients.