Faecal bile acids and clostridia in the aetiology of colorectal cancer.
Faecal bile acids and clostridia in the aetiology of colorectal cancer.
复制标题
结直肠癌病因中的粪便胆酸和梭状芽胞杆菌。
DOI：
10.1038/bjc.1980.170
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发表时间：
1980-06
影响因子：
8.8
通讯作者：
MacKay, C
中科院分区：
文献类型：
--
作者：
Murray, W R;Backwood, A;Trotter, J M;Calman, K C;MacKay, C
本研究旨在确认结直肠癌患者粪便中胆汁酸浓度增加与核扩散梭菌（NDC）相关。我们研究了37例结直肠癌患者和36例无已知胃肠道疾病的对照患者。获得粪便标本进行生化分析（总粪便胆汁酸（FBA）、石胆酸、脱氧胆酸和胆酸）和NDC分离。对照组的平均总FBA浓度（mumol/g）为20.5 +/- 2.2（s.e.）显著高于结直肠癌组（11.8 ± 0.7）（P < 0.001）。测量的个体FFA的百分比分布无统计学显著差异。NDC从64%的结直肠癌患者和15%的对照患者的粪便中分离出来，这一差异具有统计学意义（P < 0.001）。这些结果表明，能够代谢类固醇的细菌可能与结直肠癌的病因有关。然而，FBA与结直肠癌之间的关系需要进一步评估。
This study was undertaken in an attempt to confirm the increased bile-acid concentration in association with nuclear dehydrogenating Clostridia (NDC) in the faeces of colorectal cancer patients. We have studied 37 patients with colorectal cancer and 36 control patients with no known gastrointestinal disease. Stool specimens were obtained for biochemical analysis (total faecal bile acid (FBA), lithocholic deoxycholic and cholic acids) and NDC isolation. The mean total FBA concentration (mumol/g) in the control group was 20.5 +/- 2.2 (s.e.) significantly higher (P < 0.001) than the colorectal-cancer group (11.8 +/- 0.7). There was no statistically significant difference in the percentage distribution of the individual FBAs measured. NDC were isolated from the faeces of 64% of colorectal-cancer patients and 15% of control patients, this difference being statistically significant (P < 0.001). These results suggest that bacteria capable of metabolizing steroids may be implicated in the aetiology of colorectal cancer. However, the relationship between FBA and colorectal cancer requires further evaluation.