Iron state in association with retinoid metabolism in non‐alcoholic fatty liver disease
Iron state in association with retinoid metabolism in non‐alcoholic fatty liver disease
复制标题
DOI：
10.1111/j.1872-034x.2010.00719.x
复制
发表时间：
2010-12
影响因子：
4.2
通讯作者：
H. Tsuchiya;An Afida Ashla;Y. Hoshikawa;Yoshiaki Matsumi;K. Kanki;M. Enjoji;S. Momosaki;M. Nakamuta;A. Taketomi;Y. Maehara;K. Shomori;A. Kurimasa;I. Hisatome;Hisao Ito;G. Shiota
中科院分区：
文献类型：
--
作者：
H. Tsuchiya;An Afida Ashla;Y. Hoshikawa;Yoshiaki Matsumi;K. Kanki;M. Enjoji;S. Momosaki;M. Nakamuta;A. Taketomi;Y. Maehara;K. Shomori;A. Kurimasa;I. Hisatome;Hisao Ito;G. Shiota
目的：我们最近报道，在非酒精性脂肪肝（NAFLD）患者中观察到类维生素A代谢的高动力状态，这可能导致类维生素A短缺。肝脏铁超负荷，导致活性氧（ROS）的产生，也经常出现在NAFLD患者。本研究的目的是同时检测铁状态和维甲酸代谢状态，并阐明两种疾病之间的关系。
Aim: We have recently reported that hyperdynamic state of retinoid metabolism, which may lead to the shortage of retinoid, is observed in patients with non‐alcoholic fatty liver disease (NAFLD). Hepatic iron overload, which causes production of reactive oxygen species (ROS), is also frequently seen in NAFLD patients. The aim of the study is to examine iron state and retinoid metabolic state simultaneously, and to clarify the relationship between two disorders.