Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry.
Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry.
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使用可变形几何结构中的双相溶质输送分析滴注量对膀胱内输送的影响。
DOI：
10.1093/imammb/dqy004
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Zaharoff,DavidA
中科院分区：
文献类型：
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作者：
Smith,SeanG;Griffith,BoyceE;Zaharoff,DavidA
膀胱疾病通常通过膀胱内输注治疗——通过导管将治疗药物直接应用于膀胱。这项技术每年被使用数十万次，但协议的制定在很大程度上仅限于经验确定。此外，迄今为止进行的膀胱内输注的数值分析仅限于静态几何形状，并没有考虑膀胱变形。本研究采用双相溶质输运的有限元分析方法来研究与体内输送有关的几个参数，包括溶质浓度、溶质输运性质和注入体积。研究发现，输注量对溶质暴露于膀胱深层肌肉层有重大影响，而深层肌肉层通常较难到达。事实上，将输注量从50-100毫升增加，肌肉溶质暴露量占膀胱总暴露量的百分比从60-70%提高，输注量越大，肌肉溶质暴露量越高。溶质浓度或溶质输运性质的变化未见类似的增加。这些结果表明，在膀胱内输注过程中，输注量可能对膀胱的特定层起作用。
Ailments of the bladder are often treated via intravesical delivery—direct application of therapeutic into the bladder through a catheter. This technique is employed hundreds of thousands of times every year, but protocol development has largely been limited to empirical determination. Furthermore, the numerical analyses of intravesical delivery performed to date have been restricted to static geometries and have not accounted for bladder deformation. This study uses a finite element analysis approach with biphasic solute transport to investigate several parameters pertinent to intravesical delivery including solute concentration, solute transport properties and instillation volume. The volume of instillation was found to have a substantial impact on the exposure of solute to the deeper muscle layers of the bladder, which are typically more difficult to reach. Indeed, increasing the instillation volume from 50–100 ml raised the muscle solute exposure as a percentage of overall bladder exposure from 60–70% with higher levels achieved for larger instillation volumes. Similar increases were not seen for changes in solute concentration or solute transport properties. These results indicate the role that instillation volume may play in targeting particular layers of the bladder during an intravesical delivery.