PITUITARY-TESTICULAR AND PITUITARY-THYROID AXES IN SPINAL-CORD INJURED MALES
PITUITARY-TESTICULAR AND PITUITARY-THYROID AXES IN SPINAL-CORD INJURED MALES
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DOI：
10.1016/0026-0495(93)90112-2
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发表时间：
1993-04-01
影响因子：
9.8
通讯作者：
LIEN, YN
中科院分区：
文献类型：
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作者：
HUANG, TS;WANG, YH;LIEN, YN
研究人员对 30 名脊髓损伤 (SCI) 男性进行了研究，使用促黄体生成素释放激素 (LHRH) 和促甲状腺素释放激素 (TRH) 联合测试以及电射精精液分析来评估其垂体 - 睾丸和垂体 - 甲状腺轴。三十名年龄匹配的正常男性志愿者作为对照。 4 名受试者血清三碘甲状腺原氨酸 (T3) 水平较低，1 名受试者血清促卵泡激素 (FSH) 水平升高，8 名受试者血清睾酮水平升高，11 名受试者血清催乳素水平升高。与正常对照相比，SCI 受试者的黄体生成素 (LH) 对 LHRH 的反应显着升高。有 16 名 (53.3%) SCI 受试者出现过大和/或延长 LH 反应。其中，六名受试者的 FSH 反应也升高。分别有 8 名和 4 名受试者的促甲状腺素 (TSH) 和催乳素对 TRH 的反应被夸大。在来自 16 名 SCI 受试者的 56 份电射精精液样本中观察到明显的活力受损。 LH 与精子总数之间存在显着相关性。我们的数据表明 SCI 受试者的中枢多巴胺能张力降低。
Thirty spinal cord-injured (SCI) males were studied for evaluation of their pituitary-testicular and pituitary-thyroid axes using combined luteinizing hormone-releasing hormone (LHRH) and thyrotropin-releasing hormone (TRH) tests and electroejaculated semen analyses. Thirty age-matched normal male volunteers served as controls. There were four subjects with low serum triiodothyronine (T3) levels, one with elevated serum follicle-stimulating hormone (FSH) level, eight with elevated serum testosterone levels, and 11 with elevated serum prolactin levels. There were significantly elevated luteinizing hormone (LH) responses to LHRH in SCI subjects when compared with normal controls. There were 16 (53.3%) SCI subjects who had exaggerated and/or prolonged LH responses. Among them, six subjects also had elevated FSH responses. There were eight and four subjects whose thyrotropin (TSH) and prolactin responses to TRH were exaggerated, respectively. Marked impaired motility was observed in 56 electroejaculated semen samples from 16 SCI subjects. There was a significant correlation between LH and total sperm count. Our data suggest that there is a reduced central dopaminergic tone in SCI subjects.