Scan-rescan reproducibility of diastolic left ventricular kinetic energy, viscous energy loss and vorticity assessment using 4D flow MRI: analysis in healthy subjects
Scan-rescan reproducibility of diastolic left ventricular kinetic energy, viscous energy loss and vorticity assessment using 4D flow MRI: analysis in healthy subjects
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DOI：
10.1007/s10554-017-1291-z
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发表时间：
2018-06-01
影响因子：
2.1
通讯作者：
Elbaz, Mohammed S. M.
中科院分区：
文献类型：
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作者：
Kamphuis, Vivian P.;Westenberg, J. M.;Elbaz, Mohammed S. M.
本研究的目的是通过四维Flow磁共振成像(4D Flow MRI)评价健康受试者舒张期左心室(LV)动能(KE)、粘性能量损失(EL)和涡度的扫描再现性。12名志愿者(年龄27+/-3岁)在一个疗程中接受了两次全心4D Flow MRI检查。通过KE和EL的相关性来评价扫描中的一致性。计算EL指数，测量EL与舒张期KE的比值。采用扫描-再扫描分析方法，检测早期(E)和晚期(A)充盈时左室血容量的KE、EL、EL指数和涡度测量的可重复性。KE和EL的扫描一致性为强-优(E充盈SCAN1：R=0.92P<；0.001；SCAN2：Rho=0.96P<；0.001；A充盈SCAN1：Rho=0.87P<；0.001；SCAN2：R=0.99，P<；0.001)。对于大多数受试者(12人中有10人)，KE和EL测量显示出良好到很强的重复性。然而，具有广泛的一致性[组内相关(ICC)：0.64-0.95]和变异系数(CV)25%。ELindex显示，所有12名受试者都具有很强的重复性，其ICC为0.94P<；0.001，变异系数为9%。体积涡度的扫描再现性显示良好-优良的ICCs(0.83-0.95)，变异系数为11%。总而言之，目前的研究显示，4D Flow MRI评估左心室舒张期的动能、能量损失和涡度的扫描一致性很强，扫描间的一致性总体良好。然而，在十二个受试者中，有两个也发现了扫描之间在一些参数上的显著差异。在无量纲ELI中发现了很强的重复性，该指数衡量的是相对于舒张期平均动能的粘性能量损失量。
The aim of the current study was to assess the scan-rescan reproducibility of left ventricular (LV) kinetic energy (KE), viscous energy loss (EL) and vorticity during diastole from four-dimensional flow magnetic resonance imaging (4D flow MRI) in healthy subjects. Twelve volunteers (age 27 +/- 3 years) underwent whole-heart 4D flow MRI twice in one session. In-scan consistency was evaluated by correlation between KE and EL. ELindex was computed to measure the amount of EL relative to KE over diastole. Scan-rescan analysis was performed to test reproducibility of volumetric measurements of KE, EL, ELindex and vorticity in the LV over early (E) and late (A) diastolic filling. In-scan consistency between KE and EL was strong-excellent (E-filling scan1: r = 0.92, P < 0.001; scan2: rho = 0.96, P < 0.001 and A-filling scan1: rho = 0.87, P < 0.001; scan2: r = 0.99, P < 0.001). For the majority of subjects (10 out of 12), KE and EL measures showed good to strong reproducibility. However, with a wide range of agreement [intraclass correlation (ICC): 0.64-0.95] and coefficients of variation (CV) 25%. ELindex showed strong reproducibility for all 12 subjects with a strong ICC (0.94, P < 0.001) and a CV of 9%. Scan-rescan reproducibility of volumetric vorticity showed good-excellent ICCs (0.83-0.95) with CVs 11%. In conclusion, the current study shows strong-excellent in-scan consistency and overall good agreement between scans for 4D flow MRI assessment of left ventricular kinetic energy, energy loss and vorticity over diastole. However, substantial differences between the scans were also found in some parameters in two out of twelve subjects. Strong reproducibility was found in the dimensionless ELindex, which measures the amount of viscous energy loss relative to the average kinetic energy over diastole.