Estrogen and the aging brain.
Estrogen and the aging brain.
复制标题
雌激素和大脑老化。
DOI：
10.1016/s0378-5122(00)00195-x
复制
发表时间：
2001
期刊：
影响因子：
4.9
通讯作者：
Naftolin,F
中科院分区：
文献类型：
--
作者：
Silva,I;Mor,G;Naftolin,F
Evidence is presented indicating a role for estrogen in the function and maintenance of the aging brain. Based on complementary data that estrogen regulates the function of the immune–brain barrier, the hypothesis is presented that estrogen contributes to brain homeostasis via regulation of microglial activation, enabling immune-privileged status in the brain. Diminished estrogen levels during the menopause compromise the immune–brain barrier fostering inflammatory processes in the brain. This has potentially lethal consequences for brain cells, and may contribute to brain pathologies such as Alzheimer's disease.
