Specific cytogenetic changes in ovarian cancer involving chromosomes 6 and 14.
Specific cytogenetic changes in ovarian cancer involving chromosomes 6 and 14.
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发表时间：
1980-12
期刊：
影响因子：
11.2
通讯作者：
N. Wake;M. Hreshchyshyn;S. Piver;S. Matsui;A. Sandberg
中科院分区：
文献类型：
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作者：
N. Wake;M. Hreshchyshyn;S. Piver;S. Matsui;A. Sandberg
对 12 例卵巢乳头状浆液性腺癌进行了细胞遗传学研究。在这些癌症中观察到的超过 19 种克隆结构染色体异常中，6q- 和 14q+ 被发现是最常见的。两种标记物共存于八个病例的细胞中；在其他四种情况下，存在 6q- 或 14q+。在至少六例中，根据染色体数量和荧光模式，14 号染色体长臂上的额外片段似乎源自 6 号染色体的缺失部分。这表明 6q- 和 14q+ 标记分别是由于带 q21 和 q24 处相互易位而产生的，即 t(6;14)(q21;q24)。然而，在其余六例中，尚不确定是否相同类型的易位导致了标记的形成。因此，涉及 6 号和 14 号染色体的异常似乎与卵巢乳头状浆液性腺癌特别相关。
Cytogenetic studies were performed in 12 papillary serous adenocarcinomas of the ovary. Of the more than 19 clonal structural chromosome abnormalities observed in these cancers, 6q- and 14q+ were found to be the most frequent. Both markers coexisted in the cells of eight cases; in the other four cases, either a 6q- or 14q+ was present. In at least six cases, the additional segment on the long arm of chromosome 14 appeared to originate, on the basis of the chromosomal quantity and fluorescence pattern, from the missing part of chromosome 6. This suggested that the 6q- and 14q+ markers had arisen as a result of a reciprocal translocation at Bands q21 and q24, respectively, i.e., t(6;14)(q21;q24). However, it is uncertain in the remaining six cases whether an identical type of translocation was responsible for the formation of the markers. Thus, abnormalities involving chromosomes 6 and 14 seem to be specifically associated with papillary serous adenocarcinoma of the ovary.