Dehydrogenation Based Asymmetric Epoxidation of Arylalkanes to Chiral Epoxides
Dehydrogenation Based Asymmetric Epoxidation of Arylalkanes to Chiral Epoxides
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基于脱氢的芳基烷烃不对称环氧化成手性环氧化物
DOI：
10.1002/cjoc.202200304
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Zheng Huang
中科院分区：
文献类型：
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作者：
Yiting Su;Feng Yu;Guixia Liu;Zheng Huang
本文报道了通过一锅双催化剂系统实现的芳基烷烃的正式不对称环氧化，该系统包括用于烷烃脱氢-烯烃异构化（AD-ISO）的钳形Ir催化剂和用于不对称烯烃环氧化的手性酮催化剂。该方案提供了一种直接从容易获得的烷基芳烃以高区域和立体选择性以有用产率合成芳基环氧化物的催化方法。环氧化产物的立体特异性衍生化允许获得各种对映体富集的化合物。
Comprehensive SummaryWe report herein a formal asymmetric epoxidation of arylalkanes enabled by a one‐pot dual‐catalysts system comprising a pincer Ir catalyst for alkane dehydrogenation‐alkene isomerization (AD‐ISO) and a chiral ketone catalyst for asymmetric alkene epoxidation. This protocol provides a catalytic method for the synthesis of aryl epoxides in useful yields with high regio‐ and stereoselectivity directly from readily available alkyl arenes. Stereospecific derivatizations of the epoxidation product allow access to various enantioenriched compounds.