Antibodies to Prothrombin Imply a Risk of Myocardial Infarction in Middle-Aged Men
Antibodies to Prothrombin Imply a Risk of Myocardial Infarction in Middle-Aged Men
复制标题
凝血酶原抗体意味着中年男性有心肌梗塞的风险
DOI：
10.1055/s-0038-1650296
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发表时间：
1996
影响因子：
6.7
通讯作者：
T. Palosuo
中科院分区：
文献类型：
--
作者：
O. Vaarala;M. Puurunen;M. Mänttäri;V. Manninen;K. Aho;T. Palosuo
总结“抗磷脂综合征”患者体内的抗磷脂抗体可能至少部分针对血浆磷脂结合蛋白，例如β2-糖蛋白I或凝血酶原，它们参与血栓形成和止血的控制。通过酶联免疫测定法在最初健康的中年血脂异常男性（非高密度脂蛋白> 5.2 mml/1）中测量了针对凝血酶原和β2-糖蛋白I的IgG类抗体。在一项为期 5 年的吉非罗齐冠状动脉一级预防试验开始时，从 106 名在随访期间经历非致命性心肌梗死或心源性死亡的受试者以及 106 名没有冠状动脉发作的受试者中抽取血清样本，并与治疗组（吉非罗齐/安慰剂）和地理区域相匹配。患者的抗凝血酶原抗体水平（以光密度单位表示）显着高于对照组（0.26 ±0.17 对比 0.22 ±0.09；p<0.02）。高水平的抗凝血酶原抗体（最高分布三分位）预测心肌梗塞或心源性死亡的风险增加 2.5 倍（95% 置信区间 1.2-5.3）。抗（Β2-糖蛋白 I）的 IgG 类抗体的分布在病例和对照之间没有显着差异。抗凝血酶原抗体和其他与高凝状态相关的因素（甘油三酯水平、脂蛋白（a）和吸烟）的联合作用，使风险倍增。抗凝血酶原抗体是心肌梗死的新的免疫学预测因子，这些抗体的作用可能是由高凝机制介导的。
Summary Antiphospholipid antibodies in patients with “antiphospholipid syndrome” may be directed at least in part against plasma phospholipid-binding proteins, such as Β2-glycoprotein I or prothrombin, which are involved in the control of thrombosis and haemostasis. IgG-class antibodies against prothrombin and Β2-glycoprotein I were measured by enzyme-linked immunoassay in initially healthy middle-aged dyslipid-aemic men (non-high-density lipoprotein >5.2 mml/1). Serum samples had been drawn at entry to a 5-year coronary primary-prevention trial with gemfibrozil from 106 subjects who experienced either a non-fatal myocardial infarction or cardiac death during the follow-up and from 106 subjects without coronary episodes, matched for treatment group (gemfibrozil/placebo) and geographical area. The antiprothrombin antibody level, as expressed in optical density units, was significantly higher in patients than in controls (0.26 ±0.17 versus 0.22 ±0.09; p<0.02). A high level of antiprothrombin antibodies (highest tertile of distribution) predicted a 2.5-fold increase in the risk (95% confidence interval 1.2-5.3) of myocardial infarction or cardiac death. The distribution of IgG-class antibodies against (Β2-glycoprotein I did not differ significantly between cases and controls. The joint effect of antiprothrombin antibodies and other factors associated with hypercoagulative state: triglyceride level, lipoprotein(a) and smoking, was multiplicative for the risk. Antiprothrombin antibodies are a new immunological predictor of myocardial infarction and the effect of these antibodies may be mediated by hypercoagulative mechanisms.
影响因子：
20.3
作者：
Rebecca A. Fleck;S. Rapaport;Vijaya Mohan Rao
通讯作者：
Rebecca A. Fleck;S. Rapaport;Vijaya Mohan Rao
“抗心磷脂”自身抗体在缺乏磷脂的情况下识别 β2-糖蛋白 I。
DOI：
--
发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Roubey,RA;Eisenberg,RA;Harper,MF;Winfield,JB
通讯作者：
Winfield,JB