Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset.
Pulsing blue light through closed eyelids: effects on acute melatonin suppression and phase shifting of dim light melatonin onset.
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DOI：
10.2147/nss.s73856
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发表时间：
2014
影响因子：
3.4
通讯作者：
Rea MS
中科院分区：
文献类型：
--
作者：
Figueiro MG;Plitnick B;Rea MS
在老年人中，昼夜节律紊乱与睡眠障碍的患病率上升是同步的。原则上，专门针对昼夜节律系统调节的光疗法可用于治疗这一人群的睡眠障碍。目前对光治疗的建议要求患者每天至少坐在明亮的灯箱前1小时，这可能限制了他们遵守的意愿。在睡眠期间通过闭着的眼睑照射的光线不仅可以有效地改变昼夜节律，而且由于患者在睡眠期间接受光线治疗，因此依从性更好。这里报告了两项研究的结果，研究了通过闭上眼睑向视网膜照射480 nm（蓝色）光脉冲对褪黑激素抑制（实验室研究）和延迟昼夜节律阶段（现场研究）的影响。这两项研究都使用了一种睡眠面罩，它从发光二极管阵列中每30秒提供2秒持续时间的窄带蓝光脉冲。实验室研究的结果表明，蓝光脉冲显著抑制褪黑激素，其数量与之前在相同方案中显示的一半频率（即每分钟一个2秒脉冲，持续1小时）相似。实地研究的结果表明，在睡眠初期给予的蓝光脉冲显著延迟了老年人的昼夜节律；这些结果首次证明了在家庭环境中通过睡眠面罩调节昼夜节律的光治疗的有效性和实用性。
Circadian rhythm disturbances parallel the increased prevalence of sleep disorders in older adults. Light therapies that specifically target regulation of the circadian system in principle could be used to treat sleep disorders in this population. Current recommendations for light treatment require the patients to sit in front of a bright light box for at least 1 hour daily, perhaps limiting their willingness to comply. Light applied through closed eyelids during sleep might not only be efficacious for changing circadian phase but also lead to better compliance because patients would receive light treatment while sleeping. Reported here are the results of two studies investigating the impact of a train of 480 nm (blue) light pulses presented to the retina through closed eyelids on melatonin suppression (laboratory study) and on delaying circadian phase (field study). Both studies employed a sleep mask that provided narrowband blue light pulses of 2-second duration every 30 seconds from arrays of light-emitting diodes. The results of the laboratory study demonstrated that the blue light pulses significantly suppressed melatonin by an amount similar to that previously shown in the same protocol at half the frequency (ie, one 2-second pulse every minute for 1 hour). The results of the field study demonstrated that blue light pulses given early in the sleep episode significantly delayed circadian phase in older adults; these results are the first to demonstrate the efficacy and practicality of light treatment by a sleep mask aimed at adjusting circadian phase in a home setting.