Computational studies of 1-hydrazinophthalazine (hydralazine) as an antineoplasic agent.: Docking studies on methyltransferase
Computational studies of 1-hydrazinophthalazine (hydralazine) as an antineoplasic agent.: Docking studies on methyltransferase
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DOI：
10.2174/1570180054038413
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发表时间：
2005-06-01
影响因子：
1
通讯作者：
Dueñas-González, A
中科院分区：
文献类型：
--
作者：
Angeles, E;Vázquez-Valadéz, VH;Dueñas-González, A
肼苯哒嗪是一种抗高血压药物，最近报道是一种DNA甲基化抑制剂，能够使癌症中的肿瘤抑制基因去甲基化并重新激活其表达。本研究的目的是探讨肼苯哒嗪抑制DNA甲基化的可能机制。为此，我们评估了1-肼基酞嗪（肼苯哒嗪）和一个假定的配体甲基转移酶之间的结构和电子性质。
Hydralazine is a drug used as anti-hypertensive, and recently reported to be a DNA methylation inhibitor able to demethylate and reactivate the expression of tumor suppressor genes in cancer. The aim of the present study was to explore the potential mechanism by which hydralazine inhibits DNA methylation. For this purpose, we assessed the structural and electronic properties between 1-hydrazinophthalazine (hydralazine) and a putative ligand methyltransferase.