Next Generation Nerve Guides: Materials, Fabrication, Growth Factors, and Cell Delivery
Next Generation Nerve Guides: Materials, Fabrication, Growth Factors, and Cell Delivery
复制标题
DOI：
10.1089/ten.teb.2011.0498
复制
发表时间：
2012-04-01
影响因子：
6.4
通讯作者：
Haycock, John W.
中科院分区：
文献类型：
--
作者：
Bell, Juliet H. A.;Haycock, John W.
神经引导器越来越多地被用于外科手术来修复急性周围神经损伤。这不仅是由于市售器械数量的增加，也是由于临床接受度的增加。然而，再生距离通常限于20-25 mm，部分是由于基本的管状设计。许多实验研究表明，当导管结合涂层、内部支架、地形线索或递送支持细胞时，神经再生距离有所改善。目前关于设计用于最大化神经再生的神经引导件的研究集中在含细胞和无细胞装置两者上，后者作为“现成”产品在临床上具有吸引力。当导管与支持细胞结合使用时，可以获得更好的结果（例如，例如，在一个实施例中，许旺细胞或干细胞），可以提高再生距离和修复速度，并提供关于许旺细胞和神经元细胞如何在再生受损神经中响应的信息性实验数据。在这篇综述中，我们讨论了目前市售的神经导的范围，并在未来设计神经导临床使用的背景下评价实验研究。
Nerve guides are increasingly being used surgically to repair acute peripheral nerve injuries. This is not only due to an increase in the number of commercially available devices, but also clinical acceptance. However, regeneration distance is typically limited to 20-25 mm, in part due to the basic tubular design. A number of experimental studies have shown improvements in nerve regeneration distance when conduits incorporate coatings, internal scaffolds, topographical cues, or the delivery of support cells. Current studies on designing nerve guides for maximizing nerve regeneration focus both on cell-containing and cell-free devices, the latter being clinically attractive as "off the shelf" products. Arguably better results are obtained when conduits are used in conjunction with support cells (e. g., Schwann cells or stem cells) that can improve regeneration distance and speed of repair, and provide informative experimental data on how Schwann and neuronal cells respond in regenerating injured nerves. In this review we discuss the range of current nerve guides commercially available and appraise experimental studies in the context of the future design of nerve guides for clinical use.