The effect of penicillamine on the laboratory parameters in rheumatoid arthritis.
The effect of penicillamine on the laboratory parameters in rheumatoid arthritis.
复制标题
青霉胺对类风湿关节炎实验室参数的影响。
DOI：
10.1002/art.1780080606
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发表时间：
1965
影响因子：
--
通讯作者：
I. Jaffe
中科院分区：
文献类型：
--
作者：
I. Jaffe
21例类风湿关节炎患者给予青霉胺治疗4 - 6个月，每周测量RF滴度、ESR和CRP的变化。大多数患者在停药时发现这些参数中的一个或多个较初始值有所改善。对相关文献的回顾，以及最初的观察结果，对药物的作用机制提出了几种可能的解释。
Twenty‐one patients with rheumatoid arthritis were given penicillamine for periods of four to six months, and the changes in RF titer, ESR, and CRP were measured weekly. An improvement in one or more of these parameters from their initial values was found in most of the patients at the time the agent was terminated. A review of the related literature, as well as original observations, suggests several possible explanations for the mechanism of action of the drug.