Vascular endothelial growth factor in pleural fluid
Vascular endothelial growth factor in pleural fluid
复制标题
DOI：
10.1378/chest.116.3.760
复制
发表时间：
1999-09-01
期刊：
影响因子：
9.6
通讯作者：
Light, RW
中科院分区：
文献类型：
--
作者：
Cheng, DS;Rodriguez, RM;Light, RW
研究目的：本研究的目的是分析一组70例患者胸水血管内皮生长因子（VEGF）水平与诊断类别和多种液体特征的关系，设计：采用酶联免疫吸附试验测定接受治疗性胸腔穿刺术的连续患者的VEGF水平，设置：大学附属三级护理中心。充血性心力衰竭患者胸液VEGF的中位数水平（150 pg/mL）显著冠状动脉旁路移植术后的平均血流量（P < 0.05）高于中位水平（357 pg/mL），这又显著低于（p < 0.05）恶性肿瘤患者的中位数水平（1，097 pg/mL）。两组之间的重叠hct限制了胸水VEGF水平的诊断价值。VEGP水平与乳酸脱氢酶水平密切相关（r = 0.42，p < 0.001），与胸水总蛋白水平也有显著相关性。乳腺癌患者胸水中位VECF水平显著低于肺癌患者（p = 0.017）。VEGF水平是非常高的（3,201 pg/mL），在一个病人肺embolis.Conclusions：我们得出结论，胸腔积液中的VEGF水平显着不同，从一个诊断类别到另一个最高的中位数水平发生在恶性胸腔积液患者。我们推测，VEGF可能是负责胸膜液积聚在至少某些情况下。
Study objectives: The purpose of this study was to analyze the relationship of the pleural fluid vascular endothelial growth factor (VEGF) level with the diagnostic category anti with the plural fluid characteristics in a group of 70 patients,Design: The VEGF levels of consecutive patients undergoing therapeutic thoracentesis were determined with an enzyme-linked immunosorbent assay,Setting: University-affiliated tertiary care center.Results: The median level of pleural fluid VEGF in the patients with congestive heart failure (150 pg/mL) was significantly (p < 0.05) lon er than the median level in the patients with coronary artery bypass grafting (357 pg/mL), which in turn was significantly lower (p < 0.05) than the median levels in the patients with malignancy (1,097 pg/mL). The overlap hct between groups, hen-ever, limits the diagnostic usefulness of pleural fluid VEGF levels. The VEGP level was most closely correlated with the lactate dehydrogenase level (r = 0.42, p < 0.001) and was also significantly col related with die total pleural al fluid protein level. The median VECF levels in the pleural fluid of patients with breast cancer ere significantly lower (p = 0.017) than in those with lung cancer. The VEGF level was very high (3,201 pg/mL) in the one patient with pulmonary embolism.Conclusions: We conclude that the VEGF levels in pleural fluid differ significantly from one diagnostic category to another with the highest median levels occurring in patients with malignant pleural effusions. We speculate that VEGF may be responsible for the pleural al fluid accumulation in at least some situations.