Complete Freund's adjuvant suppresses the development and progression of pristane-induced arthritis in rats.
Complete Freund's adjuvant suppresses the development and progression of pristane-induced arthritis in rats.
复制标题
弗氏完全佐剂可抑制大鼠中降植烷诱导的关节炎的发生和进展。
作者：
C. Zheng;Md. Aslam Hossain;A. Kukita;K. Ohki;T. Satoh;O. Kohashi
本研究产生了新的发现，即在降植烷诱导的关节炎（PIA）发作前使用非致关节炎剂量的完全弗氏佐剂（CFA）治疗可以预防PIA的发展。令人惊讶的是，用非致关节炎和致关节炎剂量的CFA治疗几乎可以治愈正在进行的PIA。CFA治疗还抑制病理变化，如炎性细胞浸润、血管翳形成、骨破坏和新骨形成。与对照组相比，CFA抑制PIA大鼠淋巴结细胞IFN-γ mRNA表达显著增加，而IL-2、TNF-α、IL-4和IL-5 mRNA表达无显著变化。CFA对PIA的发展和进展的抑制作用的可能机制进行了讨论，在IFN-γ，一氧化氮和热休克蛋白特异性T细胞反应的抗炎作用。本研究为类风湿性关节炎的治疗提供了新的思路。
The present study produced the novel finding that treatment with a nonarthritogenic dose of Complete Freund's adjuvant (CFA) before the onset of pristane-induced arthritis (PIA) could prevent the development of PIA. Surprisingly, treatment with nonarthritogenic and arthritogenic doses of CFA could almost cure the ongoing PIA. CFA treatment also suppressed pathological changes, such as inflammatory cell infiltration, pannus formation, bone destruction, and new bone formation. The lymph node cells of rats with PIA suppressed by CFA showed significantly increased mRNA expression of IFN-gamma but no significant changes in mRNA expression of IL-2, TNF-alpha, IL-4, and IL-5 compared with those of rats in the control groups. The possible mechanisms of the suppressive effect of CFA on the development and progression of PIA were discussed in terms of the anti-inflammatory roles of IFN-gamma, nitric oxide, and heat-shock protein-specific T cell responses. The present study found a new therapeutic implication for the treatment of rheumatoid arthritis.
影响因子：
4.4
作者：
Sheldon M. Cooper;Subramaniam Sriram;G. Ranges
通讯作者：
Sheldon M. Cooper;Subramaniam Sriram;G. Ranges
BB 大鼠胰岛和甲状腺中细胞因子基因的表达。
DOI：
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发表时间：
1996
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Zipris,D;Greiner,DL;Malkani,S;Whalen,B;Mordes,JP;Rossini,AA
通讯作者：
Rossini,AA