The role of dendritic cells in cancer and anti-tumor immunity.
The role of dendritic cells in cancer and anti-tumor immunity.
复制标题
树突状细胞在肿瘤和抗肿瘤免疫中的作用。
DOI：
10.1016/j.smim.2021.101481
复制
发表时间：
2021-03
影响因子：
7.8
通讯作者：
Anandasabapathy N
中科院分区：
文献类型：
--
作者：
Marciscano AE;Anandasabapathy N
树突状细胞（DC）是宿主免疫应答的关键哨兵，在连接先天性免疫和适应性免疫以及维持耐受中起重要作用。越来越多的人认识到DC是启动和维持有效的T细胞介导的抗肿瘤免疫应答的关键决定因素。免疫肿瘤学的最新进展已经导致了不断发展的见解，即肿瘤微环境（TME）中DC的存在和功能可能决定癌症免疫疗法以及常规癌症疗法的疗效，包括免疫检查点阻断，放疗和化疗。因此，对树突状细胞免疫生物学的更好理解，特别是关注它们在T细胞引发、迁移到组织和TME中的作用，以及功能特化DC亚群的协调体内反应，将有助于更好地理解肿瘤免疫监视如何能够被利用来改善患者的结果并开发新的DC靶向治疗方法。
Dendritic cells (DC) are key sentinels of the host immune response with an important role in linking innate and adaptive immunity and maintaining tolerance. There is increasing recognition that DC are critical determinants of initiating and sustaining effective T-cell-mediated anti-tumor immune responses. Recent progress in immuno-oncology has led to the evolving insight that the presence and function of DC within the tumor microenvironment (TME) may dictate efficacy of cancer immunotherapies as well as conventional cancer therapies, including immune checkpoint blockade, radiotherapy and chemotherapy. As such, improved understanding of dendritic cell immunobiology specifically focusing on their role in T-cell priming, migration into tissues and TME, and the coordinated in vivo responses of functionally specialized DC subsets will facilitate a better mechanistic understanding of how tumor-immune surveillance can be leveraged to improve patient outcomes and to develop novel DC-targeted therapeutic approaches.
登录
查看更多内容
DOI：
10.1084/jem.20131397
发表时间：
2014-08-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Anandasabapathy N;Feder R;Mollah S;Tse SW;Longhi MP;Mehandru S;Matos I;Cheong C;Ruane D;Brane L;Teixeira A;Dobrin J;Mizenina O;Park CG;Meredith M;Clausen BE;Nussenzweig MC;Steinman RM
通讯作者：
Steinman RM
影响因子：
10.9
作者：
Buchwald ZS;Nasti TH;Lee J;Eberhardt CS;Wieland A;Im SJ;Lawson D;Curran W;Ahmed R;Khan MK
通讯作者：
Khan MK
DOI：
10.1084/jem.20170229
发表时间：
2017-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Alloatti A;Rookhuizen DC;Joannas L;Carpier JM;Iborra S;Magalhaes JG;Yatim N;Kozik P;Sancho D;Albert ML;Amigorena S
通讯作者：
Amigorena S
DOI：
10.4049/jimmunol.1700909
发表时间：
2018-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Alice AF;Kramer G;Bambina S;Baird JR;Bahjat KS;Gough MJ;Crittenden MR
通讯作者：
Crittenden MR
影响因子：
64.5
作者：
Binnewies, Mikhail;Mujal, Adriana M.;Krummel, Matthew F.
通讯作者：
Krummel, Matthew F.