NIH funding for vaccine readiness before the COVID-19 pandemic.
NIH funding for vaccine readiness before the COVID-19 pandemic.
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DOI：
10.1016/j.vaccine.2021.03.022
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发表时间：
2021-04-22
期刊：
影响因子：
5.5
通讯作者：
Ledley FD
中科院分区：
文献类型：
--
作者：
Kiszewski AE;Cleary EG;Jackson MJ;Ledley FD
新冠肺炎疫苗的快速发展依赖于现有疫苗技术的应用。这项工作检查了候选疫苗中使用的十项技术的成熟度(截至2020年7月)，以及NIH从2000年到2019年对这些技术的已发表研究的资助情况。这些技术从已成功用于批准产品的现有平台，到未经事先临床验证的新兴技术，各不相同。从2000-2019年，NIH提供了16358个财政年度总计172亿美元的资金，支持了一大批已发表的疫苗技术研究。在此期间，NIH没有为针对冠状病毒、寨卡病毒、埃博拉病毒和登革热等特定大流行威胁的已发表疫苗研究提供资金。国立卫生研究院的资金极大地促进了可用于快速开发新冠肺炎疫苗的技术的进步，这表明公共部门为快速应对新出现的公共卫生威胁的基础技术提供持续资金的重要性。
Rapid development of vaccines for COVID-19 has relied on the application of existing vaccine technologies. This work examines the maturity of ten technologies employed in candidate vaccines (as of July 2020) and NIH funding for published research on these technologies from 2000–2019. These technologies vary from established platforms, which have been used successfully in approved products, to emerging technologies with no prior clinical validation. A robust body of published research on vaccine technologies was supported by 16,358 fiscal years of NIH funding totaling $17.2 billion from 2000–2019. During this period, NIH funding for published vaccine research against specific pandemic threats such as coronavirus, Zika, Ebola, and dengue was not sustained. NIH funding contributed substantially to the advance of technologies available for rapid development of COVID-19 vaccines, suggesting the importance of sustained public sector funding for foundational technologies in the rapid response to emerging public health threats.
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影响因子：
3.7
作者：
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通讯作者：
Ledley FD
影响因子：
5.5
作者：
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Gilbert, Sarah
DOI：
10.1136/amiajnl-2011-000213
发表时间：
2011-07-01
影响因子：
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作者：
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通讯作者：
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影响因子：
1
作者：
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通讯作者：
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