Low level exposure to manganese from drinking water and cognition in school-age children
Low level exposure to manganese from drinking water and cognition in school-age children
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DOI：
10.1016/j.neuro.2017.07.024
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发表时间：
2018-01-01
期刊：
影响因子：
3.4
通讯作者：
Foucher, Delphine
中科院分区：
文献类型：
--
作者：
Bouchard, Maryse F.;Surette, Celine;Foucher, Delphine
背景资料：锰（Mn）是一种存在于环境中的元素，某些地理区域由于自然条件或人类活动而在土壤和水中的浓度升高。越来越多的数据表明，暴露于饮用水中的锰可能是neurotoxic.Objective：首先，我们的目的是研究饮用水中的锰暴露和认知之间的关联在儿童饮用井水。其次，我们还旨在研究认知和锰浓度之间的关系，在儿童的头发，指甲，和salipha.Methods：共259名儿童从189户饮用井水被列入本研究（年龄5.9至13.7岁）。我们用WISC-IV评估儿童的认知，我们使用了五个锰暴露指标：自来水浓度，饮水量除以儿童体重，儿童头发，脚趾甲和唾液中的锰浓度。我们使用通用估计方程分析来评估锰暴露指标和智商得分之间的关系，调整潜在的混杂因素，并考虑到家庭cluster.Results：饮用水锰浓度普遍较低，48%的儿童饮用水50 μ g/L，4% >400 μ g/L。结果因性别而异。在女孩中，水、头发和脚趾甲中锰浓度较高与表现智商评分较差相关，但仅脚趾甲中有显著性（锰浓度增加10倍，β：-5.65，95%CI：-10.97，-0.32）。在男孩中观察到相反的关联，即，头发、脚趾甲和水的锰浓度较高时，表现智商得分更高，后者具有显着性β：2.66，95%CI：0.44，4.89）。言语智商分数似乎没有与锰暴露indicators.Conclusions：饮用水锰水平大大低于以前的研究报告的神经毒性作用。在学龄儿童样本中，没有明确的迹象表明锰暴露与认知发育之间存在关联，尽管数据表明可能存在性别特异性关联。鉴于暴露水平低和性别特异性关联，需要更大的样本量来增加统计功效并更好地描述关系。(C)2017爱思唯尔B. V.保留所有权利。
Background: Manganese (Mn) is an element found in the environment and certain geographic areas have elevated concentrations in soil and water du to natural conditions or anthropic activities. A growing body of data suggests that exposure to manganese in drinking water could be neurotoxic.Objective: Firstly, we aimed to examine the association between exposure to manganese from drinking water and cognition in children consuming well water. Secondly, we also aimed to examine the relation between cognition and manganese concentrations in children's hair, nail, and saliva.Methods: A total 259 children from 189 households consuming well water were included in the present study (ages 5.9 to 13.7 years). We assessed children's cognition with the WISC-IV, and we used five indicators of manganese exposure: concentration in tap water, intake from the consumption of water divided by child's weight, manganese concentration in children's hair, toe nail, and saliva. We used General Estimating Equation analysis to assess the relation between manganese exposure indicators and IQ scores, adjusting for potential confounders, and taking into account family clusters.Results: Drinking water manganese concentrations were generally low, with 48% of children consuming water 50 mu g/L, and 4% >400 mu g/L. Results differed by sex. In girls, higher manganese concentration in water, hair, and toe nail were associated with poorer Performance IQ scores but this was significant only for toe nail (for a 10-fold increase in manganese, beta: -5.65, 95% CIs: -10.97, -0.32). Opposite associations were observed in boys, i.e., better Performance IQ scores with higher manganese concentration hair, toe nail, and water, the latter being significant beta: 2.66, 95% CIs: 0.44, 4.89). Verbal IQ scores did not seem to be associated with manganese exposure indicators.Conclusions: Drinking water manganese levels were considerably lower than in previous studies reporting neurotoxic effects. There was no clear indication of an association between exposure to manganese and cognitive development in this sample of school-age children although the data suggest there might be sex-specific associations. Given the low levels of exposure and sex-specific associations, a larger sample size would have been required to increase the statistical power and better characterize the relations. (C) 2017 Elsevier B.V. All rights reserved.