Expression and role of cadherins in astrocytic tumors.
Expression and role of cadherins in astrocytic tumors.
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DOI：
10.1007/bf02478865
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发表时间：
1997-01-01
影响因子：
3.3
通讯作者：
Suzuki, S
中科院分区：
文献类型：
--
作者：
Asano, K;Kubo, O;Suzuki, S
钙粘蛋白是一种钙离子依赖的细胞粘附分子，在多细胞生物的组织形成和形态发生中起重要作用。近年来，有报道钙粘蛋白参与肿瘤的侵袭和转移。对22例手术标本及部分培养细胞进行免疫组化染色。在间变性星形细胞瘤患者中没有观察到显著差异，而在胶质母细胞瘤患者中，在复发时检测到N-钙粘蛋白表达降低。在这些组中，发现脑脊液播散，并观察到对侧脑转移和颅外转移。我们的结论是，免疫组织化学显示复发时间与肿瘤侵袭和脑脊液扩散相关，N-钙粘蛋白表达减少。
Cadherins are Ca(2+)-dependent cell adhesion molecules that play an important role in tissue formation and morphogenesis in multicellular organisms. In recent years, there have been reports of cadherin involvement in tumor invasion and metastasis. Twenty-two surgical specimens and some cultured cells were studied by immunohistochemical staining. No significant difference was observed in the patients with anaplastic astrocytoma, whereas decreased expression of N-cadherin was detected at the time of recurrence in those with glioblastoma. In these groups, cerebrospinal fluid dissemination was found, and contralateral cerebral metastases and extracranial metastases were observed. We conclude that decreased N-cadherin expression at the immunohistochemically demonstrated time of recurrence correlates with tumor invasion and dissemination of cerebrospinal fluid.