Physical limits to biochemical signaling
Physical limits to biochemical signaling
复制标题
DOI：
10.1073/pnas.0504321102
复制
发表时间：
2005-07-19
影响因子：
11.1
通讯作者：
Setayeshgar, S
中科院分区：
文献类型：
--
作者：
Bialek, W;Setayeshgar, S
许多重要的生物过程都是在数量少得令人惊讶的分子中进行的，人们对分析与这些小数量相关的噪声的影响重新产生了兴趣。25年前，贝格和珀塞尔发现细菌的趋化性，即单细胞生物必须对细胞外化学物质浓度的微小变化做出反应，直接受到分子计数噪音的限制，细菌的行为和计算策略必须选择最小化这种噪音的影响。在这里，我们重新审视和概括他们的论点，以估计细胞内信号传导过程的物理限制，并认为最近的实验与接近这些限制的性能是一致的。
Many crucial biological processes operate with surprisingly small numbers of molecules, and there is renewed interest in analyzing the impact of noise associated with these small numbers. Twenty-five years ago, Berg and Purcell showed that bacterial chemotaxis, where a single-celled organism must respond to small changes in concentration of chemicals outside the cell, is limited directly by molecule counting noise and that aspects of the bacteria's behavioral and computational strategies must be chosen to minimize the effects of this noise. Here, we revisit and generalize their arguments to estimate the physical limits to signaling processes within the cell and argue that recent experiments are consistent with performance approaching these limits.