Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora -: II.: Structural studies
Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora -: II.: Structural studies
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DOI：
10.7164/antibiotics.51.402
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发表时间：
1998-04-01
影响因子：
3.3
通讯作者：
Oka, T
中科院分区：
文献类型：
--
作者：
Hori, H;Igarashi, Y;Oka, T
用光谱技术确定了酪氨酸特异性蛋白激酶的抑制剂组胺A、B、C、D和G的结构。本报告中描述的Hibarimicins由一个共同的苷元和六个脱氧己糖组成。配基中含有高度氧化的萘基对苯二酚作为生色团。其中，Hibarimicin B与angelmicin B相同。
The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.