Penicillamine-induced elastosis perforans serpiginosa treated successfully with isotretinoin.
Penicillamine-induced elastosis perforans serpiginosa treated successfully with isotretinoin.
复制标题
异维A酸成功治疗青霉胺诱导的穿孔弹性组织变性。
作者：
R. Ratnavel;P. Norris
穿孔性丝状线虫弹性增生（EPS）和弹性假黄色瘤（PXE）的弹性改变是罕见的，但众所周知的副作用，长期青霉胺治疗。一位42岁的女性患者在接受大剂量青霉胺治疗威尔逊氏病后出现了这两种皮肤副作用。尽管继续使用青霉胺，但异维甲酸（0.5 mg/kg/天）治疗6周后，EPS几乎完全消失，但PXE没有消失。
Elastosis perforans serpiginosa (EPS) and the elastotic changes of pseudoxanthoma elasticum (PXE) are rare but well-recognized side-effects of long-term penicillamine therapy. A 42-year old female patient who developed both of these cutaneous side-effects following treatment with high-dose penicillamine for Wilson's disease is described; near-complete resolution of the EPS, but not the PXE was achieved by treatment with isotretinoin (0.5 mg/kg/day) for 6 weeks, despite continuation of the penicillamine.