Subcutaneous implantation for the biological evaluation of endodontic materials.
Subcutaneous implantation for the biological evaluation of endodontic materials.
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DOI：
10.1016/s0099-2399(81)80057-x
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发表时间：
1981-08-01
影响因子：
4.2
通讯作者：
Langeland, K
中科院分区：
文献类型：
--
作者：
Olsson, B;Sliwkowski, A;Langeland, K
皮下植入聚四氟乙烯管作为牙髓材料的载体，对其作为测试这些材料的生物相容性的方法的适用性进行了评估。使用了三种代表性类型的根管封闭剂。将装有密封剂的管子放入 143 只大鼠的皮下组织中。观察期为14、30、90和180天。急性和慢性炎症细胞的出现，巨噬细胞、异物巨细胞和血管中物质的存在，表明所有封闭剂都具有刺激性和可吸收性。每组内组织反应的严重程度差异很大。结论是，植入方法对于牙髓材料的定性评估是实用的，但材料的生物相容性排名仅适用于毒性相当不同的材料。
The subcutaneous implantation of Teflon tubes as carriers for endodontic materials was evaluated for its suitability as a method for the testing of the biocompatibility of these materials. Three representative types of root canal sealers were used. Tubes filled with sealers were placed in the subcutaneous tissue of 143 rats. The observation periods were 14, 30, 90, and 180 days. The occurrence of acute and chronic inflammatory' cells, presence of material in macro phages, foreign body giant cells, and vessels, demonstrated that all sealers were irritating and resorbable. The severity of the tissue response varied widely within each group. It was concluded that the implantation method was practical for the qualitative evaluation of endodontic materials, but that a ranking of biocompat- ibility of materials would be possible only for materials of considerably different toxicity.