Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome.
Exploring Linkages between Taxonomic and Functional Profiles of the Human Microbiome.
复制标题
DOI：
10.1128/msystems.00163-17
复制
发表时间：
2018-03
期刊：
影响因子：
6.4
通讯作者：
Langille MGI
中科院分区：
文献类型：
--
作者：
Langille MGI
微生物组研究通常侧重于表征群落内微生物的分类和功能概况。一般认为功能分析上级分类分析，用于研究人类-微生物相互作用，但现有方法存在一些限制和挑战。微生物组研究通常侧重于表征群落内微生物的分类和功能概况。一般认为功能分析上级分类分析，用于研究人类-微生物相互作用，但现有方法存在一些限制和挑战。该观点讨论了目前用于产生分类和功能概况的测序和生物信息学方法，利用和比较这些技术的最新研究，以及这些数据的现有挑战和局限性。此外，功能与分类保护整个人口的质疑，而未来的研究，重点是调查微生物功能的分类多样性提出了建议。
Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing approaches. Microbiome studies typically focus on characterizing the taxonomic and functional profiles of the microbes within a community. Functional profiling is generally thought to be superior to taxonomic profiling for investigating human-microbe interactions, but there are several limitations and challenges to existing approaches. This Perspective discusses the current sequencing and bioinformatic methods for producing taxonomic and functional profiles, recent studies utilizing and comparing these technologies, and the existing challenges and limitations of these data. In addition, functional versus taxonomic conservation across the population is questioned, while future research that focuses on investigating the taxonomic diversity of microbial functions is proposed.