Insights into mechanisms of immunotherapy circa 1943: "What has been will be again".

Insights into mechanisms of immunotherapy circa 1943: "What has been will be again".
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1943 年左右对免疫治疗机制的见解:“已有之事,必将再次发生”。

DOI:
10.1016/j.anai.2023.01.035
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发表时间:
2023
期刊:
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
影响因子:
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通讯作者:
Borish,Larry
Borish,Larry
中科院分区:
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文献类型:
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作者:
Borish,Larry

文献摘要

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在年鉴的第一年,我们的祖先努力确定成功的过敏免疫疗法(AIT)的分子机制。我现在可以用一个简单的声明来结束这篇评论,那就是80年后的今天,我们仍然在为同一个问题而挣扎。然而,有趣和值得评论的是,这些调查者有多少是正确的,并解释传道书引用的上述标题,“太阳之下确实没有新事。”同样特别令人高兴的是,这本书的作者都是新英格兰医学中心的教员,这位评论员后来在大约40年后担任他的第一个教员职务。
In the inaugural year of the Annals, our forebears struggled with the question of determining the molecular mechanisms of successful allergy immunotherapy (AIT). I can end this commentary now with the simple statement that it is 80 years later and we are still struggling with the same question.What is intriguing and worthy of commentary, however, is how much these investigators got right and to paraphrase the Ecclesiastes quote from the above title,“there truly is nothing new under the sun.” It is also particularly pleasing that the authors of this work were both faculty members at the New England Medical Center, a location where this commentator would later assume his first faculty appointment some 40 years later.