Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: Results from a cross-sectional general population study
Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: Results from a cross-sectional general population study
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DOI：
10.1016/j.pain.2013.04.043
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发表时间：
2013-09-01
期刊：
影响因子：
7.4
通讯作者：
Goebel, Andreas
中科院分区：
文献类型：
--
作者：
Goodson, Nicola J.;Smith, Blair H.;Goebel, Andreas
为了探讨慢性疼痛是否与心血管危险因素相关，并确定疼痛分布或强度的增加是否与心血管风险相关，苏格兰一代：苏格兰家庭健康研究的参与者完成了疼痛调查问卷，记录以下内容：慢性疼痛的存在、疼痛的分布和慢性疼痛的强度。记录血压、血脂、血糖、吸烟史、腰臀比、体重指数；计算了弗雷明汉 10 年冠心病 (CHD) 风险评分，并得出代谢综合征的诊断。研究人员探讨了慢性疼痛与心血管风险之间的关联。在 13,328 名参与者中，1100 名（8.3%）有较高的 CHD 风险。 5209 人 (39%) 报告慢性疼痛，1294 人 (9.7%) 报告广泛慢性疼痛，707 人 (5.3%) 报告高强度慢性疼痛。在年龄和性别调整分析中，慢性疼痛与冠心病风险评分升高（比值比 1.11，95% 置信区间 1.01-1.23）和代谢综合征（比值比 1.42，95% 置信区间 1.24-1.62）相关。多变量分析发现血脂异常、年龄、性别、吸烟、肥胖和高腰臀比与慢性疼痛独立相关。在慢性疼痛亚组中，广泛的疼痛不会带来任何额外的心血管疾病风险。然而，导致代谢综合征的心血管疾病危险因素在那些报告高强度慢性疼痛的人中更为普遍。这项基于人群的大型研究表明，慢性疼痛，特别是高强度慢性疼痛，与心血管危险因素和代谢综合征患病率增加有关。 10 年冠心病风险评分和代谢综合征与疼痛强度增加密切相关，但与广泛的疼痛无关。 (c) 2013 年国际疼痛研究协会。由 Elsevier B.V. 出版。保留所有权利。
To explore whether chronic pain is associated with cardiovascular risk factors and identify whether increased distribution or intensity of pain is associated with cardiovascular risk, participants in Generation Scotland: The Scottish Family Health study completed pain questionnaires recording the following: presence of chronic pain, distribution of pain, and intensity of chronic pain. Blood pressure, lipids, blood glucose, smoking history, waist-hip ratio, and body mass index were recorded; Framingham 10-year coronary heart disease (CHD) risk scores were calculated and a diagnosis of metabolic syndrome derived. Associations between chronic pain and cardiovascular risk were explored. Of 13,328 participants, 1100 (8.3%) had high CHD risk. Chronic pain was reported by 5209 (39%), 1294 (9.7%) reported widespread chronic pain, and 707 (5.3%) reported high-intensity chronic pain. In age- and gender-adjusted analyses, chronic pain was associated with elevated CHD risk scores (odds ratio 1.11, 95% confidence interval 1.01-1.23) and the metabolic syndrome (odds ratio 1.42, 95% confidence interval 1.24-1.62). Multivariate analyses identified dyslipidaemia, age, gender, smoking, obesity, and high waist-hip ratio as independently associated with chronic pain. Within the chronic pain subgroup, widespread pain did not confer any additional cardiovascular disease risk. However, cardiovascular disease risk factors contributing to metabolic syndrome were more prevalent in those reporting high-intensity chronic pain. This large population-based study has demonstrated that chronic pain, and in particular high-intensity chronic pain, is associated with an increased prevalence of cardiovascular risk factors and metabolic syndrome. The 10-year CHD risk score and metabolic syndrome correlate well with increased pain intensity, but not with widespread pain. (c) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.