Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice
Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice
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DOI：
10.1016/j.jphs.2018.09.006
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发表时间：
2018-09-01
影响因子：
3.5
通讯作者：
Minami, Masabumi
中科院分区：
文献类型：
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作者：
Deyama, Satoshi;Shimoda, Kento;Minami, Masabumi
二十碳五烯酸 (EPA) 衍生的消退素 E1 (RvE1) 和 E2 (RvE2) 具有抗抑郁作用。在这里，我们研究了 resolvin E3 (RvE3) 在脂多糖 (LPS) 诱导的抑郁症小鼠模型中的抗抑郁作用。我们观察到，LPS（0.8 mg/kg，腹腔注射）显着增加了悬尾试验中的不动时间，并且这种抑郁样行为通过脑室内输注 RvE3（10 或 100 ng）呈剂量依赖性减弱。没有观察到 LPS 或脑室内输注 RvE3 对运动活动的影响。这些结果表明 RvE3 以及 RvE1 和 RvE2 具有抗抑郁作用。 (C) 2018 作者。由 Elsevier B.V. 制作和主持
Eicosapentaenoic acid (EPA)-derived resolvin E1 (RvE1) and E2 (RvE2) have antidepressant effects. Here, we investigated the antidepressant effects of resolvin E3 (RvE3) in a mouse model of lipopolysaccharide (LPS)-induced depression. We observed that LPS (0.8 mg/kg, i.p.) significantly increased immobility time on the tail suspension test, and this depression-like behavior was dose-dependently attenuated by intracerebroventricular infusion of RvE3 (10 or 100 ng). No effects of LPS or intracerebroventricular infusion of RvE3 on locomotor activity were observed. These results indicate that RvE3, as well as RvE1 and RvE2, have antidepressant effects. (C) 2018 The Authors. Production and hosting by Elsevier B.V.