Vaccination and autoimmune rheumatic diseases
Vaccination and autoimmune rheumatic diseases
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DOI：
10.1016/j.autrev.2008.07.007
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发表时间：
2008-12-01
影响因子：
13.6
通讯作者：
Valesini, Guido
中科院分区：
文献类型：
--
作者：
Conti, Fabrizio;Rezai, Soheila;Valesini, Guido
患有自身免疫性风湿病的患者发生感染的风险增加。然而，对疫苗在这些患者中的安全性和免疫原性的担忧限制了它们的使用。大多数反对使用疫苗的数据来自报告的病例，这些人在接种疫苗后出现风湿病发作，然而因果关系尚未建立。在过去的几十年里，给系统性红斑狼疮患者接种流感和肺炎球菌疫苗被发现是安全的，通常在血清学上是有效的，尽管存在反应不足的可能性，特别是在接受免疫抑制剂的患者。在类风湿性关节炎患者中，流感和肺炎球菌疫苗在大多数情况下可以被认为是安全的和免疫原性的。用肿瘤坏死因子α阻断剂治疗似乎不会损害免疫反应。(C)2008爱思唯尔B.V.保留所有权利。
Patients with autoimmune rheumatic diseases are at increased risk of developing infections. However, concerns about the safety and the immunogenicity of vaccines in these patients limited their use. Most of the data against the use of vaccines come from the reported cases of previously healthy individuals who presented the onset of rheumatic diseases after immunization, nevertheless a causal relationship has not been established.During the past few decades influenza and pneumococcal vaccines, administered to patients with systemic lupus erythematosus, were found to be safe and, generally, serologically effective, even though there is the possibility of inadequate response, especially in patients receiving immunosuppressive agents. In patients with rheumatoid arthritis influenza and pneumococcal vaccines can be considered safe and immunogenic in most cases. Treatment with TNF alpha blocking agents did not appear to impair the immune response. (C) 2008 Elsevier B.V. All rights reserved.