Surface Active Phospholipids as Cartilage Lubricants
Surface Active Phospholipids as Cartilage Lubricants
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作为软骨润滑剂的表面活性磷脂
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
S. Sivan
中科院分区：
文献类型：
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作者：
Avi Schroeder;G. Verberne;Y. Merkher;D. Diminsky;A. Maroudas;G. Halperin;D. Nitzan;I. Etsion;Y. Barenholz;S. Sivan
有效的润滑和极低的摩擦对于滑膜关节的正常功能至关重要。各种关节功能障碍与摩擦力或粘附力增加直接相关。众所周知，表面活性磷脂（SAPL）可减少滑膜关节的摩擦。这项研究表明，使用一种新的人源软骨-软骨设置，由SAPL二肉豆蔻酰磷脂酰胆碱（DMPC）组成的多层囊泡（MLV）作为有效润滑剂的潜力，将静态和动态摩擦系数降低到健康滑膜关节的水平。此外，发现由DMPC组成的MLV（尺寸范围为0.8 - 103.5 μm）是比组氨酸缓冲液、生理盐水或滑液更有效的润滑剂。讨论了使用本文所述的装置在很大程度上模拟自然条件测试新软骨润滑剂的能力。
Efficient lubrication and extremely low friction are essential for proper functioning of synovial joints. Various joint dysfunctions were described in direct association with increased friction or adhesive forces. Surface-active phospholipids (SAPLs) are well known to reduce friction in synovial joints. This study demonstrates, using a novel human-sourced cartilage-on-cartilage setup, the potential of multilamellar vesicles (MLV) composed of the SAPL dimyristoyl phosphatidylcholine (DMPC) to act as effective lubricants, reducing static and dynamic friction-coefficients to levels of healthy synovial joints. Furthermore, MLV composed of DMPC, in sizes ranging from 0.8 to ∼3.5 μm, were found to be more effective lubricants than histidine buffer, saline, or synovial fluid. The ability to test new cartilage lubricants, simulating, to a great extent, natural conditions, using the setup presented herein is discussed.Copyright © 2008 by ASME