INFLUENZA-VIRUS NEURAMINIDASE - STRUCTURE, ANTIBODIES, AND INHIBITORS
INFLUENZA-VIRUS NEURAMINIDASE - STRUCTURE, ANTIBODIES, AND INHIBITORS
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DOI：
10.1002/pro.5560031007
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发表时间：
1994-10-01
期刊：
影响因子：
8
通讯作者：
COLMAN, PM
中科院分区：
文献类型：
--
作者：
COLMAN, PM
1983年对流感病毒神经氨酸酶三维结构的测定为了解抗体和蛋白抗原之间的相互作用、研究流感病毒的抗原变异以及设计新的酶抑制剂提供了一个平台。这里回顾了这项工作，以及最近的进展，其中一种抑制剂已作为抗流感病毒药物进入临床试验。
The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for understanding interactions between antibodies and protein antigens, for investigating antigenic variation in influenza viruses, and for devising new inhibitors of the enzyme. That work is reviewed here, together with more recent developments that have resulted in one of the inhibitors entering clinical trials as an anti-influenza virus drug.