INTRACEREBROVENTRICULAR INFUSION OF RU28318 BLOCKS ALDOSTERONE-SALT HYPERTENSION
INTRACEREBROVENTRICULAR INFUSION OF RU28318 BLOCKS ALDOSTERONE-SALT HYPERTENSION
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DOI：
10.1152/ajpendo.1990.258.3.e482
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发表时间：
1990-03-01
影响因子：
--
通讯作者：
GOMEZSANCHEZ, CE
中科院分区：
文献类型：
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作者：
GOMEZSANCHEZ, EP;FORT, CM;GOMEZSANCHEZ, CE
在大鼠和狗的慢性侧脑室（icv）注入醛固酮，在10-14天内升高血压，剂量远低于引起全身性高血压的剂量。在大鼠中的作用是剂量依赖性的，并被同时icv输注的抗盐皮质激素，prorenone阻断。本文报道了另一种特异性盐皮质激素受体拮抗剂RU 28318对皮下注射醛固酮致敏大鼠高血压的影响。微渗透泵用于皮下递送1 μ g/h醛固酮和icv递送1.1 μ g/h RU 8318。在24天的时间内，对照组、RU 28318 icv组和醛固酮sc + RU 28318 icv组的间接收缩压从105 mmHg升高至123 mmHg，并且彼此之间没有显著差异，而醛固酮sc组升高至156 mmHg。RU 28318，icv或sc，没有改变醛固酮sc产生的尿量增加，组间体重无显著差异。这项研究提供了证据的重要性，中枢神经系统在高血压的发病机制所产生的全身性盐皮质激素过量。
The chronic intracerebroventricular (icv) infusion of aldosterone in rats and dogs elevates the blood pressure within 10-14 days at doses far below those that produce hypertension systemically. The effect in rats is dose dependent and blocked by the concomitant icv infusion of the antimineralocorticoid, prorenone. The effect of the icv infusion of RU28318, another specific spironolactone mineralocorticoid antagonist, on the hypertension produced by chronic subcutaneous (sc) administration of aldosterone in sensitized rats was reported. Miniosmotic pumps were used to deliver 1 .mu.g/h aldosterone sc and 1.1 .mu.g/h RU8318 icv. Over a 24-day period the indirect systolic blood pressure of the control, RU28318 icv, and aldosterone sc plus RU28318 icv groups increased from 105 to 123 mmHg and were not significantly different from each other, whereas the aldosterone sc group increased to 156 mmHg. RU28318, icv or sc, did not alter the increase in urine volume produced by aldosterone sc, and there was no significant differences in weight between the groups. This study provides evidence of the importance of the central nervous system in the pathogenesis of hypertension produced by systemic mineralocorticoid excess.