Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity.
Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity.
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DOI：
10.3389/fphys.2020.543148
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发表时间：
2020
影响因子：
4
通讯作者：
Kong Y
中科院分区：
文献类型：
--
作者：
Zhang H;Qi J;Wang Y;Sun J;Li Z;Sui L;Fan J;Liu C;Shang Y;Kong L;Kong Y
成功的胚胎着床需要接受性子宫内膜，这有利于胚胎在一定时间内的识别、粘附和侵入过程，与17β-雌二醇（E2）和孕酮（P4）的动态相互作用密不可分。适当的葡萄糖代谢对于子宫内膜进入接受状态的深刻生理变化至关重要。葡萄糖转运蛋白（glucose transporters，GLUT）是葡萄糖代谢的第一步，负责细胞内葡萄糖的摄取。先前文献报道了子宫内膜中存在GLUT。然而，我们仍然不了解这一过程的具体机制。在这项研究中，我们确定了P4对葡萄糖转运蛋白1（GLUT 1）的影响，在体内动物模型，并确定了葡萄糖代谢的调节细胞中的P4。我们高度怀疑这种妊娠失败可能是由于GLUT 1介导的葡萄糖代谢减少，导致能量供应和底物合成不足引起的子宫内膜容受性降低。在这里，我们提出了一个可能的机制来解释胚胎植入是如何影响P4和葡萄糖利用异常子宫内膜条件下。
Successful embryo implantation requires receptive endometrium, which is conducive to the process of embryo recognition, adhesion, and invasion within a certain period of time and is inseparable from the dynamic interaction between 17β-estradiol (E2) and progesterone (P4). Proper glucose metabolism is critical for the profound physiological changes in the endometrium entering the receptive state. And glucose transporters (GLUTs) are responsible for intracellular uptake of glucose and are the first step in glucose metabolism. Prior literature has reported the presence of GLUTs in the endometrium. However, we still do not understand the specific mechanisms of this process. In this study, we identified the effect of P4 on glucose transporter 1 (GLUT1) using in vivo animal models and determined the regulation of glucose metabolism by P4 in cells. We highly suspect that this pregnancy failure may be due to reduced GLUT1-mediated glucose metabolism, resulting in a decrease in endometrial receptivity caused by an inadequate energy supply and synthesis of substrate. Here, we propose a possible mechanism to explain how embryo implantation is affected by P4 and glucose utilization under abnormal endometrial conditions.
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