Importance of associative learning processes for one-trial behavioral sensitization of preweanling rats.
Importance of associative learning processes for one-trial behavioral sensitization of preweanling rats.
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DOI：
10.1097/fbp.0b013e32834affb2
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发表时间：
2011-10
影响因子：
1.6
通讯作者：
Flores AT
中科院分区：
文献类型：
--
作者：
McDougall SA;Pothier AG;Der-Ghazarian T;Herbert MS;Kozanian OO;Castellanos KA;Flores AT
在成年期，联想学习是必要的表达一次审判的行为敏感化，但是，它是不确定的，是否相同的联想过程中，在断奶前期间的操作。采用两种策略来评估联想学习对断奶前大鼠一次性行为敏化的重要性。在最初的实验中，我们改变了条件刺激（CS，新的环境）和非条件刺激（US，可卡因）之间的顺序和时间间隔。在最后的实验中，我们确定ECS诱导的逆行性遗忘是否会破坏一次试验的行为敏化。结果表明，无论可卡因和新环境（推定CS）的顺序如何，强烈的致敏反应都是明显的。改变CS和US表现之间的时间（0、3或6小时）也没有影响。实验3的结果表明，单次或多次ECS处理不改变致敏反应的表达。因此，这些数据表明，一次试验的行为敏化断奶前大鼠完全介导的非联想机制和联想过程不调制敏化反应。这些发现与成年期的观察结果相反，因为成年大鼠只有在联想过程起作用时才会表现出一次性行为敏化。
During adulthood, associative learning is necessary for the expression of one-trial behavioral sensitization; however, it is uncertain whether the same associative processes are operative during the preweanling period. Two strategies were used to assess the importance of associative learning for the one-trial behavioral sensitization of preweanling rats. In the initial experiments, we varied both the sequence and time interval between presentation of the conditioned stimulus (CS, novel environment) and unconditioned stimulus (US, cocaine). In the final experiment, we determined whether ECS-induced retrograde amnesia would disrupt one-trial behavioral sensitization. Results showed that robust sensitized responding was apparent regardless of the sequence in which cocaine and the novel environment (the presumptive CS) were presented. Varying the time between CS and US presentation (0, 3, or 6 h) was also without effect. Results from Experiment 3 showed that single or multiple ECS treatments did not alter the expression of the sensitized response. Therefore, these data indicated that the one-trial behavioral sensitization of preweanling rats was exclusively mediated by nonassociative mechanisms and that associative processes did not modulate sensitized responding. These findings are in contrast to what is observed during adulthood, because adult rats exhibit one-trial behavioral sensitization only when associative processes are operative.