CONTRIBUTION OF THE AMYGDALA TO LEARNING AND PERFORMANCE OF CONDITIONAL FEAR
CONTRIBUTION OF THE AMYGDALA TO LEARNING AND PERFORMANCE OF CONDITIONAL FEAR
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DOI：
10.1016/0031-9384(92)90320-2
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发表时间：
1992-06-01
影响因子：
2.9
通讯作者：
HELMSTETTER, FJ
中科院分区：
文献类型：
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作者：
HELMSTETTER, FJ
杏仁核复合体似乎是神经系统中介导某些形式的厌恶巴甫洛夫条件反射的重要组成部分。这种结构的相对贡献收购和恐惧条件反射过程中的性能进行了评估，在杏仁核的临时病变之前，培训或保留测试在一个单一的审判巴甫洛夫条件反射准备。微量注射盐酸利多卡因（5.0%，1.0 μ l）到杏仁核前的CS信号足电击导致条件性恐惧的性能显着衰减，作为指标的时间量大鼠在保留会话期间从事防御冻结行为。然而，在训练课程之前用利多卡因进行类似的治疗，在此期间CS和UCS配对，仅导致随后的反应微弱降低。因此，虽然收购和性能相关的过程发生在杏仁核，它似乎是后者更敏感的中断使用本程序。这些结果进行了讨论，在厌恶学习和动机的过程中，这种结构所发挥的一般作用。
The amygdaloid complex appears to be an essential component in the neural systems mediating some forms of aversive Pavlovian conditioning. The relative contribution of this structure to acquisition and performance during fear conditioning was assessed by making temporary lesions in the amygdala prior to training or retention testing in a single-trial Pavlovian conditioning preparation. Microinjection of lidocaine HCl (5.0%, 1.0-mu-l) into the amygdala prior to the presentation of a CS signalling footshock resulted in a significant attenuation of the performance of conditional fear, as indexed by the amount of time rats spent engaged in defensive freezing behavior during the retention session. However, similar treatment with lidocaine prior to the training session, during which the CS and UCS were paired, resulted in only a weak reduction in subsequent responding. Thus, while both acquisition- and performance-related processes take place within the amygdala, it appears that the latter are more sensitive to disruption using the present procedures. These results are discussed in terms of the general role played by this structure in aversive learning and motivational processes.