Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth.
Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth.
复制标题
在黑色素瘤生长过程中，调节性T细胞（TREG）和髓样衍生抑制细胞（MDSC）之间的串扰。
DOI：
10.4161/onci.21176
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发表时间：
2012-11-01
期刊：
影响因子：
7.2
通讯作者：
Aiba S
中科院分区：
文献类型：
--
作者：
Fujimura T;Kambayashi Y;Aiba S
髓源性抑制细胞（MDSCa）是促进荷瘤宿主中免疫抑制环境的异质细胞群体。最近，据报道B7-H1信号传导对于调节性T细胞（Tcells）（另一种免疫抑制细胞群）的恶性肿瘤至关重要。在这里，我们讨论了B7-H1对MDSCs的免疫抑制功能，以及TGFAP和MDSCs之间的功能串扰。
Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.