Inverse Relationship between the Inflammatory Marker Pentraxin-3, Fat Body Mass, and Abdominal Obesity in End-Stage Renal Disease
Inverse Relationship between the Inflammatory Marker Pentraxin-3, Fat Body Mass, and Abdominal Obesity in End-Stage Renal Disease
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DOI：
10.2215/cjn.02320311
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发表时间：
2011-12-01
影响因子：
9.8
通讯作者：
Carrero, Juan Jesus
中科院分区：
文献类型：
--
作者：
Miyamoto, Tetsu;Qureshi, Abdul Rashid;Carrero, Juan Jesus
研究背景与目的正五聚蛋白3（Pentraxin-3，PTX 3）与C反应蛋白（C-reactive protein，CRP）同属急性时相反应物正五聚蛋白超家族。ESRD中的腹部脂肪积聚被认为是一种慢性炎症状态，但PTX 3与这种现象的关系尚不清楚。本研究评估了PTX 3和透析患者脂肪量沉积替代物之间的合理关联。设计、设置、参与者和测量在两个队列中，包括156名流行性血液透析（HD）和216名事件透析患者，对PTX 3、CRP和IL-6的循环水平与脂肪组织的人体测量和营养替代标记物进行了横断面分析。PTX 3与人体测量学和瘦素得出的体重指数（BMI）和脂肪体重指数（FBMI）呈负相关，而与脂联素呈正相关。在流行的HD患者中，腰围较大（高于性别特异性中位数）的患者具有较低的PTX 3、较高的CRP和较高的IL-6水平。在多变量分析中也是如此。在这两个队列中，多变量回归分析显示，PTX 3呈负相关，CRP（或IL-6）与FBMI.Conclusions虽然CRP和IL-6直接与体脂，PTX 3水平呈负相关与脂肪组织的替代品在两个独立的队列的ESRD患者。了解这些相反关联背后的潜在原因可能具有临床意义，因为肥胖患者透析的生存优势。Clin J Am Soc Nephrol 6：2785-2791，2011. doi：10.2215/CJN.02320311
Background and objectives Pentraxin-3 (PTX3) belongs to the same pentraxin superfamily of acute-phase reactants as (C-reactive protein (CRP). Abdominal fat accumulation in ESRD is considered a chronic inflammatory state, but the relationship of PTX3 to this phenomenon is unknown. This study assesses plausible associations between PTX3 and surrogates of fat mass deposits in dialysis patients.Design, setting, participants, & measurements Circulating levels of PTX3, CRP, and IL-6 were cross-sectionally analyzed in relation to anthropometric and nutritional surrogate markers of fat tissue in two cohorts comprising 156 prevalent hemodialysis (HD) and 216 incident dialysis patients.Results In both cohorts, PTX3 was negatively associated with body mass index (BMI) and fat body mass index (FBMI) derived from anthropometrics and leptin, whereas there was a positive association with adiponectin. In prevalent HD patients, those with larger waist circumference (above gender-specific median values) had lower PTX3, higher CRP, and higher IL-6 levels. This was also true in multivariate analyses. In both cohorts, multivariate regression analyses showed that PTX3 was negatively and CRP (or IL-6) was positively associated with FBMI.Conclusions Although CRP and IL-6 were directly associated with body fat, PTX3 levels showed negative correlations with surrogates of adipose tissue in two independent cohorts of ESRD patients. Understanding the underlying reasons behind these opposite associations may have clinical relevance given the survival advantage described for obese patients on dialysis. Clin J Am Soc Nephrol 6: 2785-2791, 2011. doi: 10.2215/CJN.02320311