An innate interaction between IL-18 and the propeptide that inactivates its precursor form
An innate interaction between IL-18 and the propeptide that inactivates its precursor form
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IL-18 和前肽之间的先天相互作用使其前体形式失活
DOI：
10.1038/s41598-019-42661-5
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Hidenori Ohnishi & Hidehito Tochio
中科院分区：
文献类型：
--
作者：
Naotaka Tsutsumi;Ayumi Yokota;Takeshi Kimura;Zenichiro Kato;Toshiyuki Fukao;Masahiro Shirakawa;Hidenori Ohnishi & Hidehito Tochio
成熟白细胞介素（IL）-1β和IL-18的不受控制的分泌是严重的自身炎症或自身免疫性疾病和各种过敏性疾病的原因。在这里，我们报告了IL-18和其前肽之间的分子内相互作用，该前肽在成熟过程中从其前体proIL-18中蛋白水解除去。使用重组前肽在分子间重现分子内相互作用。这些结果表明，开发一类新的基于肽的IL-18抑制剂，可以作为IL-18相关的炎症性疾病的治疗剂的可能性。
Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated intermolecularly using recombinant propeptide. These results suggest the possibility of developing a novel class of peptide-based IL-18 inhibitors that could serve as therapeutic agents for IL-18-related inflammatory diseases.