Pituitary Tumors in Mice after Prolonged Feeding of Synthetic Progestins
Pituitary Tumors in Mice after Prolonged Feeding of Synthetic Progestins
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长期喂食合成孕激素后小鼠的垂体肿瘤
DOI：
10.1126/science.154.3747.402
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发表时间：
1966
期刊：
影响因子：
56.9
通讯作者：
W. Poel
中科院分区：
文献类型：
--
作者：
W. Poel
在C57 Leaden品系的未交配雌性小鼠中观察到合成孕激素重复口服给药后垂体瘤的发展增强。这一发现似乎与孕酮重复治疗的C3H小鼠中引发的乳腺肿瘤发展的共致癌性增强平行。
An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins. This finding appears to parallel the co-carcinogenic enhancement of mammary tumor development elicited in C3H mice treated repeatedly with progesterone.