Role of vascular risk factors and vascular dysfunction in Alzheimer's disease.
Role of vascular risk factors and vascular dysfunction in Alzheimer's disease.
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DOI：
10.1002/msj.20155
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发表时间：
2010-01
影响因子：
--
通讯作者：
Hof, Patrick R.
中科院分区：
文献类型：
--
作者：
Dickstein, Dara L.;Walsh, Jessica;Brautigam, Hannah;Stockton, Steven D., Jr.;Gandy, Samuel;Hof, Patrick R.
关键词：
最近的研究结果表明，血管危险因素和神经血管功能障碍在阿尔茨海默病的发病机制中起着不可或缺的作用。除了衰老，阿尔茨海默病最常见的危险因素是载脂蛋白e4等位基因、高血压、低血压、糖尿病和高胆固醇血症。所有这些都可以通过归因于诸如脑淀粉样血管病和随后的血脑屏障功能障碍等病症的血管病理学来表征。许多流行病学、临床和药理学研究已经评估了这些危险因素与阿尔茨海默病之间的关联，并发现高血压、低血压和糖尿病之间存在正相关。然而，这些基于人群的研究仍有许多相互矛盾的结果，应仔细解释。认识到这些因素及其导致阿尔茨海默病的机制将有利于目前阿尔茨海默病的治疗方案和未来疗法的发展。在这里，我们讨论血管因素与阿尔茨海默病和痴呆症，并审查的因素，引起血管功能障碍，并有助于阿尔茨海默病。
Recent findings indicate that vascular risk factors and neurovascular dysfunction play integral roles in the pathogenesis of Alzheimer's disease. In addition to aging, the most common risk factors for Alzheimer's disease are apolipoprotein e4 allele, hypertension, hypotension, diabetes, and hypercholesterolemia. All of these can be characterized by vascular pathology attributed to conditions such as cerebral amyloid angiopathy and subsequent blood-brain barrier dysfunction. Many epidemiological, clinical, and pharmacotherapeutic studies have assessed the associations between such risk factors and Alzheimer's disease and have found positive associations between hypertension, hypotension, and diabetes mellitus. However, there are still many conflicting results from these population-based studies, and they should be interpreted carefully. Recognition of these factors and the mechanisms by which they contribute to Alzheimer's disease will be beneficial in the current treatment regimens for Alzheimer's disease and in the development of future therapies. Here we discuss vascular factors with respect to Alzheimer's disease and dementia and review the factors that give rise to vascular dysfunction and contribute to Alzheimer's disease.
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