Assessment of gastric motor function by cine magnetic resonance imaging
Assessment of gastric motor function by cine magnetic resonance imaging
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DOI：
10.1111/j.1440-1746.2009.05891.x
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发表时间：
2009-08-01
影响因子：
4.1
通讯作者：
Wakabayashi, Go
中科院分区：
文献类型：
--
作者：
Baba, Shigeaki;Sasaki, Akira;Wakabayashi, Go
背景与目的：本研究的目的是通过磁共振成像（MRI）评估胃运动功能，并探讨该检查是否为治疗疗效或术后胃运动功能的有用工具。方法：25名健康志愿者和10例胃癌保幽门胃切除术（PPG）患者行mri扫描。采用3d容积法测定胃容积。通过计算胃动力指数（GMI）来量化胃动力。结果：所有受试者均成功完成图像采集和分析。健康志愿者在进食果冻30 min后胃蠕动波的平均频率、振幅、速度和GMI分别为3/min、8.8 mm、2.2 mm/s和19.6 mm(2)/s。给予枸橼酸莫沙匹利（MS）后30min，平均振幅（8.8 vs 10.4 mm, P = 0.027）、流速（2.2 vs 2.6 mm/s, P < 0.001）和GMI （19.6 vs 26.7 mm(2)/s, P < 0.001）显著增加。MS给药后平均胃容量显著降低；0分钟（317.3 vs 272.9 mL, P = 0.021）， 45分钟（263.4 vs 206.4 mL, P = 0.004）和60分钟（228.7 vs 165 mL, P = 0.001）。有餐后症状的PPG患者出现类似反蠕动的收缩波，胃内容物从幽门区返流到胃上部。有餐后症状的PPG患者在进食果冻后30分钟的平均胃容量往往大于无餐后症状的患者。结论：本研究表明，cine-MRI是一种灵敏、无创的同时测量胃运动和排空的成像技术。
Background and Aim:The aim of the present study was to evaluate gastric motor function by magnetic resonance imaging (MRI) and investigate whether this examination is a useful tool for therapeutic efficacy or postoperative gastric motor function.Methods:Twenty-five healthy volunteers and 10 gastric cancer patients with pylorus-preserving gastrectomy (PPG) underwent cine-MRI. Gastric volume was determined by 3D-volumetry. Gastric motility was quantified by calculating the gastric motility index (GMI).Results:The image acquisition and analysis were successfully carried out for all subjects. In healthy volunteers, mean frequency, amplitude, velocity of gastric peristaltic waves and GMI 30 min after the intake of jelly were 3/min, 8.8 mm, 2.2 mm/s and 19.6 mm(2)/s, respectively. Mean amplitude (8.8 vs 10.4 mm, P = 0.027), velocity (2.2 vs 2.6 mm/s, P < 0.001) of peristaltic waves, and GMI (19.6 vs 26.7 mm(2)/s, P < 0.001) significantly increased at 30 min after giving mosapride citrate (MS). Mean gastric volume after MS administration was significantly decreased; 0 min (317.3 vs 272.9 mL, P = 0.021), 45 min (263.4 vs 206.4 mL, P = 0.004) and 60 min (228.7 vs 165 mL, P = 0.001). PPG patients with postprandial symptoms were observed having antiperistalsis-like contraction waves and reflux of gastric contents from the pyloric region into the upper part of the stomach. Mean gastric volume in PPG patients with postprandial symptoms at 30 min after intake of jelly tended to be greater than in those without such symptoms.Conclusions:The present study demonstrates that cine-MRI is a sensitive and non-invasive imaging technique for simultaneously measuring gastric motility and emptying.