Effects of opioids on proliferation of mature and immature immune cells.
Effects of opioids on proliferation of mature and immature immune cells.
复制标题
阿片类药物对成熟和未成熟免疫细胞增殖的影响。
DOI：
10.1007/978-1-4615-2980-4_5
复制
发表时间：
1993
影响因子：
--
通讯作者：
Lee,NM
中科院分区：
文献类型：
--
作者：
Loh,HH;Smith,AP;Lee,NM
大量且不断增长的证据表明，使用阿片类药物可以改变免疫系统功能。人们早就知道阿片类药物成瘾者会增加多种传染病的发病率 (1) 以及许多免疫参数的改变。在给实验动物施用阿片类药物后，还观察到免疫系统的各种变化（综述，请参阅 (2)。然而，迄今为止，几乎所有关于阿片类药物-免疫关联的研究都集中在成熟的免疫细胞上。所有循环细胞都来自骨髓中的多能干细胞，它们通过涉及几种特定淋巴因子的复杂过程增殖和分化为成熟的免疫细胞和红细胞。因此，任何作用于干细胞的滥用药物都可能会导致免疫系统发生变化。作为解决这个问题的方法，我们长期使用吗啡治疗小鼠，然后分离它们的骨髓细胞并测试它们对通常诱导这些细胞亚群增殖和/或分化的几种细胞因子的敏感性 (3)。
A large and growing body of evidence indicates that the use of opioid drugs can alter immune system functioning. It has long been known that opioid addicts suffer from an increased incidence of a variety of infectious diseases (1), as well as alterations in a number of immune parameters. A variety of changes in the immune system has also been observed following administration of opioids to laboratory animals (for review, see (2). However, almost all work on opioid-immune associations to date has focussed on mature immune cells. All circulating cells arise from pluripotent stem cells in the bone marrow, which proliferate and differentiate, by means of a complex process involving several specific lymphokines, into mature immune cells and erythrocytes. Any drug of abuse acting on stem cells therefore might have potent, wide ranging effects on the immune system. As an approach to this question, we treated mice chronically with morphine, then isolated their bone marrow cells and tested their sensitivity to several cytokines that normally induce proliferation and/or differentiation of subpopulations of these cells (3).