Carboxyhemoglobin levels as an index of hemolysis.
Carboxyhemoglobin levels as an index of hemolysis.
复制标题
碳氧血红蛋白水平作为溶血指标。
作者：
R. Engel;F. Rodkey;C. Krill
在血红素的分解代谢过程中，一氧化碳（CO）和胆红素以等摩尔量形成。在证明加速溶血增加内源性CO形成时，重要的是要分离出可变外源性CO暴露的影响。229例正常儿童血碳氧血红蛋白饱和度0.6 ~ 3.9%，平均1.30% （sd = 0.47%）。40例溶血性疾病患儿循环血红蛋白CO饱和率为0.8 ~ 4.0%，平均为1.95% （sd = 0.88%）。在正常儿童中观察到的六倍范围主要是由于不同的环境CO暴露，因为574个不吸烟的成年人在呼吸相同的气体混合物超过18小时的比较中，总是给出的碳氧血红蛋白值相差不到0.35%饱和度。通过将疑似溶血患者的血液CO含量与暴露于相同外源性CO水平数小时的正常兄弟姐妹或另一个对照个体进行比较，可以获得内源性CO形成增加的定性指标。37例已知溶血性疾病患儿的碳氧血红蛋白水平始终高于其匹配的环境对照组。
Carbon monoxide (CO) and bilirubin are formed in equimolar amounts during the catabolism of heme. In demonstrating increased endogenous CO formation from accelerated hemolysis it is important to separate out the effect of variable exogenous CO exposure. The carboxyhemoglobin level in 229 normal children ranged from 0.6 to 3.9% saturation, with a mean of 1.30% (S.D. = 0.47%). Forty children with hemolytic diseases had from 0.8 to 4.0% of their circulating hemoglobin saturated with CO with a mean of 1.95% (S.D. = 0.88%). The sixfold range observed in normal children is largely due to variable ambient CO exposure, since 574 comparisons between nonsmoking adults who were breathing the same gas mixture for over 18 hours, always gave carboxyhemoglobin values which differed by less than 0.35% saturation. By comparing the blood CO content of a suspect hemolytic patient with a normal sibling or another control individual who has been exposed to the same exogenous CO level for several hours, it is possible to obtain a qualitative index of increased endogenous CO formation. Thirty-seven children with known hemolytic disease always had carboxyhemoglobin levels which were higher than their matched environmental controls.