The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction
The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction
复制标题
DOI：
10.1016/j.mad.2016.03.006
复制
发表时间：
2016-06-01
影响因子：
5.3
通讯作者：
Watson, Rachel E. B.
中科院分区：
文献类型：
--
作者：
Langton, Abigail K.;Halai, Poonam;Watson, Rachel E. B.
人类皮肤的真皮-表皮连接处表现出与年龄相关的重塑，导致外观扁平和表面积减少。尽管如此，关于哪些蛋白质成分随着年龄的增长而变化的信息仍然很少。在这里，我们报告了在固有老化皮肤中胶原IV（P < 0.0001）、胶原VII（P < 0.001）、胶原XVII（P < 0.01）、整合素β 4（P < 0.001）和层粘连蛋白-332（P < 0.0001）的蛋白分布的显著减少。这种改变的蛋白质组成的功能含义似乎是结构完整性的丧失，并且可以部分地解释老化皮肤的脆性增加。(C)2016作者出版社：Elsevier爱尔兰Ltd.
The dermal-epidermal junction of human skin exhibits age-related remodelling, resulting in a flattened appearance and reduced surface area. Despite this, a paucity of information is available regarding which protein components change with advancing age. Here we report a significant reduction in the protein distribution of collagen IV (P < 0.0001), collagen VII (P < 0.001), collagen XVII (P < 0.01), integrin beta 4 (P < 0.001) and laminin-332 (P < 0.0001) in intrinsically aged skin. The functional implication of this altered protein composition appears to be loss of structural integrity and may, in part, explain the increased fragility of aged skin. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.