Helicobacter pylori Infection and Gastric Adenocarcinoma.
Helicobacter pylori Infection and Gastric Adenocarcinoma.
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发表时间：
2011-06
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通讯作者：
P. Correa;M. Piazuelo
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作者：
P. Correa;M. Piazuelo
胃腺癌是全球癌症相关死亡的第二大原因。幽门螺杆菌感染是公认的胃腺癌最强的危险因素。这种细菌寄生在世界上一半以上人口的胃中；然而，只有极少数的感染者会发展为腺癌。幽门螺杆菌引起的慢性胃炎可能持续数十年，而最常见的胃腺癌组织学类型（肠型）则被认为是多步骤的癌前过程。这种感染的严重程度和长期结果受到越来越多的细菌、宿主和环境因素的调节，这些因素以复杂的方式相互作用。识别出胃癌高危个体并在癌前过程中进行监测和干预是降低这种恶性肿瘤死亡率的最合适策略。
Gastric adenocarcinoma is the second leading cause of cancer-related mortality worldwide. Infection with Helicobacter pylori is the strongest recognized risk factor for gastric adenocarcinoma. This bacterial species colonizes the stomach of more than half of the world's population; however, only a very small proportion of infected subjects develop adenocarcinoma. H. pylori causes a chronic gastritis that may last decades, and a multistep precancerous process is recognized for the most frequent histologic type of gastric adenocarcinoma: the intestinal type. The severity and long-term outcome of this infection is modulated by an increasing list of bacterial, host, and environmental factors, which interplay in a complex manner. Identification of individuals at high risk for gastric cancer that may enter a surveillance program and intervention during the precancerous process is the most suitable strategy for decreasing mortality due to this malignancy.