A suite of asymmetric citrate siderophores isolated from a marine Shewanella species
A suite of asymmetric citrate siderophores isolated from a marine Shewanella species
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DOI：
10.1016/j.jinorgbio.2019.110736
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发表时间：
2019-09-01
影响因子：
3.9
通讯作者：
Butler, Alison
中科院分区：
文献类型：
--
作者：
Carmichael, Jeffrey R.;Zhou, Hongjun;Butler, Alison
Woodybactins A-D 是由发光海洋细菌 Shewanella woodyi MS32 产生的一套新型脂肪酰基铁载体。虽然这种细菌具有一组与需氧菌素生物合成基因簇同源的基因，但不产生需氧菌素。与大肠杆菌和其他产生类似于需氧菌素的铁载体的物种相比，S. woodyi MS32 中这些基因在基因组内的排列有所不同，并且将第二个酰基羟基赖氨酸附加到柠檬酸末端羧酸盐上的合成酶基因不起作用。在木杆菌素 A-D 套件中，其脂肪酸附属物有所不同，其中一种含有不寻常的 C-9 (9:0) 脂肪酸，一种含有独特的支链 C-9 异 (9:0 异) 脂肪酸，以及 C-8 (8:0) 和 C-10 (10:0) 脂肪酸。
Woodybactins A-D are a suite of new fatty acyl siderophores produced by the luminous marine bacterium Shewanella woodyi MS32. While this bacterium has a set of genes homologous to the biosynthetic gene cluster for aerobactin, aerobactin is not produced. The arrangement of these genes within the genome differs in S. woodyi MS32 when compared to E. coli and other species producing siderophores similar to aerobactin, and one synthetase gene which would append a second acyl-hydroxylysine to the terminal carboxylate of citrate is not functional. Within the suite of woodybactins A-D, which differ by the fatty acid appendage, one contains an unusual C-9 (9:0) fatty acid and one contains a unique branched C-9 iso (9:0 iso) fatty acid, as well as a C-8 (8:0) and C-10 (10:0) fatty acid.