The association between depressive mood and cognitive performance in an elderly general population - The MEMO study
The association between depressive mood and cognitive performance in an elderly general population - The MEMO study
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DOI：
10.1159/000093745
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Berger, Klaus
中科院分区：
文献类型：
--
作者：
Baune, Bernhard T.;Suslow, Thomas;Berger, Klaus
本研究的目的是分析老年人抑郁症状的严重程度对不同领域的认知功能的影响。在一项基于人群的横断面研究中，385名年龄在65 - 83岁之间的参与者接受了流行病学研究中心抑郁量表（CES-D）的采访，并进行了标准化的神经心理学测试，评估注意力，记忆力，认知速度和运动功能。多元线性回归分析显示，抑郁症状对一项测试（Stroop测试1）和两项总分（记忆和运动功能）有显著影响。经教育和简易精神状态检查完全校正后，记忆分数部分衰减。分层分析显示，与那些具有高度抑郁症状的参与者相比，CES-D评分的增加导致轻度至中度抑郁症状的参与者的认知测试结果下降幅度更大。我们的研究结果表明，老年人的抑郁情绪主要与处理速度和运动功能下降有关，但与执行控制功能无关。根据我们的研究结果，抑郁情绪不一定与老年人的记忆缺陷有关。轻度抑郁情绪中抑郁症状的变化与认知功能的下降有关，而非重度抑郁情绪。版权所有（C）2006 S. Karger AG，巴塞尔。
The aim of this study was to analyse the influence of the severity of depressive symptoms on different domains of cognitive function in the elderly. In a population-based cross-sectional study, 385 participants aged 65 - 83 years were interviewed with the Center for Epidemiologic Studies Depression Scale (CES-D) and performed a standardized neuropsychological test assessing attention, memory, cognitive speed and motor function. Multivariate linear regression analyses revealed a significant effect of depressive symptoms on a single test (Stroop test 1) and two summary scores ( memory and motor function). After full adjustment for education and Mini Mental State Examination, the memory score was partly attenuated. Stratified analysis showed that an increase in CES-D scores led to a larger decline of cognitive test results in participants with mild to moderate depressive symptoms, compared to those with a high degree of depressive symptoms. Our results suggest that depressive mood in older adults is primarily associated with decreased processing speed and motor functioning, but not executive control functions. According to our results depressive mood is not necessarily associated with memory deficits in older adults. Changes in depressive symptoms in milder forms of depressive mood are associated with a larger decline in cognitive function than in severer forms of depressive mood. Copyright (C) 2006 S. Karger AG, Basel.